A randomized controlled dose-escalation study of SSS07, a humanized rabbit anti-human TNF alpha antibody, in healthy Chinese adults.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105807
Abstract: AIMS SSS07 is a rabbit derived humanized anti-human TNF-α antibody. This study aimed to explore the pharmacokinetics, safety, and immunogenicity of SSS07 when administrated subcutaneously in healthy adults. METHODS This was a double-blind, dose-escalation study… read more here.
Keywords: human tnf; tnf; sss07; antibody ... See more keywords
Diagnostic methods for the measurement of human TNF-alpha in clinical laboratory.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.113010
Abstract: Measurement of Tumour Necrosis Factor alpha (TNF-α) in peripheral blood is a useful tool to assess inflammatory responses in a large range of diseases. One of the major challenges for cytokine analysis is the availability… read more here.
Keywords: human tnf; tnf; tnf alpha; diagnostic methods ... See more keywords
Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-36969-x
Abstract: Tumour necrosis factor (TNF) is a key cytokine during inflammatory responses and its dysregulation is detrimental in many inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. Here, we used a bacterial artificial chromosome… read more here.
Keywords: inflammatory responses; human tnf; tnf luc; inflammatory ... See more keywords
Human IL-17 and TNF-α Additively or Synergistically Regulate the Expression of Proinflammatory Genes, Coagulation-Related Genes, and Tight Junction Genes in Porcine Aortic Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.857311
Abstract: Immune rejection is the major limitation for porcine xenograft survival in primate recipients. Proinflammatory cytokines play important roles in immune rejection and have been found to mediate the pathological effects in various clinical and experimental… read more here.
Keywords: coagulation; additively synergistically; expression; human tnf ... See more keywords
A De Novo Optimized Cell-Free System for the Expression of Soluble and Active Human Tumor Necrosis Factor-Alpha
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11020157
Abstract: Simple Summary As a result of increasing demand for the pleiotropic cytokine TNF-α, recombinant human TNF-α protein with appropriate bioactivities was produced in several heterologous in vivo expression systems. While in vivo expression of this… read more here.
Keywords: system; cell free; human tnf; expression ... See more keywords