Human topoisomerase inhibition and DNA/BSA binding of Ru(II)–SCAR complexes as potential anticancer candidates for oral application
Sign Up to like & getrecommendations! Published in 2017 at "BioMetals"
DOI: 10.1007/s10534-017-0008-z
Abstract: Three ruthenium(II) phosphine/diimine/picolinate complexes were selected aimed at investigating anticancer activity against several cancer cell lines and the capacity of inhibiting the supercoiled DNA relaxation mediated by human topoisomerase IB (Top 1). The structure–lipophilicity relationship… read more here.
Keywords: human topoisomerase; dna; bsa; anticancer ... See more keywords
Structural basis for allosteric regulation of Human Topoisomerase IIα
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DOI: 10.1038/s41467-021-23136-6
Abstract: The human type IIA topoisomerases (Top2) are essential enzymes that regulate DNA topology and chromosome organization. The Topo IIα isoform is a prime target for antineoplastic compounds used in cancer therapy that form ternary cleavage… read more here.
Keywords: human topoisomerase; structural basis; allosteric regulation; basis allosteric ... See more keywords
Synthesis, human topoisomerase IIα inhibitory properties and molecular modeling studies of anti-proliferative curcumin mimics
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DOI: 10.1039/c9ra05661k
Abstract: Piperidinecarboxamides (curcumin mimics) show promising anti-proliferative properties against HCT116 (colon), MCF7 (breast) and A431 (squamous skin) carcinoma cell lines with potency higher than that of 5-fluorouracil. read more here.
Keywords: human topoisomerase; anti proliferative; synthesis human; topoisomerase inhibitory ... See more keywords