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Published in 2019 at "eLife"
DOI: 10.7554/elife.45222
Abstract: Mammalian two-pore channels (TPCs) regulate the physiological functions of the endolysosome. Here we present cryo-EM structures of human TPC2 (HsTPC2), a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)-activated, Na+ selective channel, in the ligand-bound and apo states. The apo…
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Keywords:
human tpc2;
mechanisms phospholipid;
phospholipid activation;
structural mechanisms ... See more keywords