Molecular basis of human trace amine-associated receptor 1 activation
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DOI: 10.1038/s41467-023-44601-4
Abstract: hTA1 is a drug target for several neuropsychiatric disorders. Using cryo-EM and pharmacological assays, the authors illuminate hTA1’s similarity to neurotransmitter receptors and discover that the antipsychotic asenapine potently activates the receptor. The human trace… read more here.
Keywords: receptor; human trace; pharmacology; amine associated ... See more keywords
Validation of a High-Throughput Calcium Mobilization Assay for the Human Trace Amine-Associated Receptor 1
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DOI: 10.1177/2472555220945279
Abstract: The human trace amine-associated receptor 1 (hTAAR1) is a G protein-coupled receptor (GPCR) that is widely expressed in monoaminergic nuclei in the central nervous system and has therapeutic potential for multiple diseases, including drug addiction… read more here.
Keywords: htaar1; human trace; calcium; mobilization ... See more keywords