Histidine tracts in human transcription factors: insight into metal ion coordination ability
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biological Inorganic Chemistry"
DOI: 10.1007/s00775-017-1512-x
Abstract: Consecutive histidine repeats are chosen both by nature and by molecular biologists due to their high affinity towards metal ions. Screening of the human genome showed that transcription factors are extremely rich in His tracts.… read more here.
Keywords: histidine; tracts human; factors insight; human transcription ... See more keywords
The cryo-electron microscopy structure of human transcription factor IIH
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature23903
Abstract: Human transcription factor IIH (TFIIH) is part of the general transcriptional machinery required by RNA polymerase II for the initiation of eukaryotic gene transcription. Composed of ten subunits that add up to a molecular mass… read more here.
Keywords: factor iih; transcription; microscopy; transcription factor ... See more keywords
STEM-26. COMPREHENSIVE FUNCTIONAL GENOMIC SCREENS REVEAL HUMAN TRANSCRIPTION FACTORS REQUIRED TO MAINTAIN GLIOBLASTOMA OLIGODENDROCYTE PROGENITOR CELL-LIKE IDENTITY
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0333
Abstract: For glioblastoma (GBM), like other solid tumors, intratumoral heterogeneity is likely a critical factor in promoting tumor growth, homeostasis, and therapeutic response. Recent applications of single-cell genomics techniques have revealed the scope and nature of… read more here.
Keywords: stem; glioblastoma; cell; human transcription ... See more keywords