Investigating binding mechanism of thymoquinone to human transferrin, targeting Alzheimer's disease therapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30299
Abstract: Iron deposition in the central nervous system (CNS) is one of the causes of neurodegenerative diseases. Human transferrin (hTf) acts as an iron carrier present in the blood plasma, preventing it from contributing to redox… read more here.
Keywords: thymoquinone; alzheimer disease; human transferrin; htf ... See more keywords
Point Mutations in TbpA Abrogate Human Transferrin Binding in Neisseria gonorrhoeae
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00414-22
Abstract: TonB-dependent transporters (TDTs) are essential proteins for metal acquisition, an important step in the growth and pathogenesis of many pathogens, including Neisseria gonorrhoeae, the causative agent of gonorrhea. There is currently no available vaccine for… read more here.
Keywords: neisseria gonorrhoeae; transferrin; transferrin binding; human transferrin ... See more keywords
Unraveling human transferrin-tryptamine interactions: a computational and biophysical approach to Alzheimer’s disease therapeutics
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1540736
Abstract: Neurodegeneration is a progressive loss of neurons that leads to affected cognitive and motor functions and is characterized by neurodegenerative disorders (NDs). Human transferrin (Htf) is a blood plasma glycoprotein that binds to iron and… read more here.
Keywords: alzheimer disease; tryptamine; iron; human transferrin ... See more keywords
Unraveling Binding Mechanism of Alzheimer’s Drug Rivastigmine Tartrate with Human Transferrin: Molecular Docking and Multi-Spectroscopic Approach towards Neurodegenerative Diseases
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DOI: 10.3390/biom9090495
Abstract: Studying drug–protein interactions has gained significant attention lately, and this is because the majority of drugs interact with proteins, thereby altering their structure and, moreover, their functionality. Rivastigmine tartrate (RT) is a drug that is… read more here.
Keywords: rivastigmine tartrate; drug; human transferrin; spectroscopy ... See more keywords