Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells
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DOI: 10.3389/fimmu.2019.01532
Abstract: The CD4+FOXP3+ regulatory T cell (Treg) subset is an indispensable mediator of immune tolerance. While high and stable expression of the transcription factor FOXP3 is considered a hallmark feature of Treg cells, our previous studies… read more here.
Keywords: treg cells; human treg; foxp3; function ... See more keywords
mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.899975
Abstract: Regulatory T cells (Tregs) have shown great promise as a means of cellular therapy in a multitude of allo- and auto-immune diseases—due in part to their immunosuppressive potency. Nevertheless, the clinical efficacy of human Tregs… read more here.
Keywords: human treg; mtorc1 inhibition; apoptosis; regulatory cells ... See more keywords