Immunoproteasome activation enables human TRIM5α restriction of HIV-1
Sign Up to like & getrecommendations! Published in 2019 at "Nature microbiology"
DOI: 10.1038/s41564-019-0402-0
Abstract: Type 1 interferon suppresses viral replication by upregulating the expression of interferon-stimulated genes with diverse antiviral properties1. The replication of human immunodeficiency virus type 1 (HIV-1) is naturally inhibited by interferon, with the steps between… read more here.
Keywords: restriction; hiv; infection; interferon ... See more keywords
Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor Functioning
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13020320
Abstract: Human immunodeficiency virus-1 (HIV-1) persists as a global health concern, with an incidence rate of approximately 2 million, and estimated global prevalence of over 35 million. Combination antiretroviral treatment is highly effective, but HIV-1 patients… read more here.
Keywords: hiv; trim5; hiv restriction; human trim5 ... See more keywords