LIN28B regulates androgen receptor in human trophoblast cells through Let‐7c
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23226
Abstract: LIN28B is an RNA‐binding protein necessary for maintaining pluripotency in stem cells and plays an important role in trophoblast cell differentiation. LIN28B action on target gene function often involves the Let‐7 miRNA family. Previous work… read more here.
Keywords: lin28b; trophoblast; cells let; trophoblast cells ... See more keywords
Role of ARID1A in the Regulation of Human Trophoblast Migration and Invasion
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive Sciences"
DOI: 10.1007/s43032-021-00686-0
Abstract: Migration and invasion of trophoblasts is critical for human placental development, trophoblastic differentiation, and pregnancy-associated diseases. AT-rich interactive domain-containing protein 1A (ARID1A), a subunit of the SWI-SNF complex, has been suggested to participate in the… read more here.
Keywords: invasion; jeg cell; migration; human trophoblast ... See more keywords
TGF-β1 inhibits human trophoblast cell invasion by upregulating cyclooxygenase-2.
Sign Up to like & getrecommendations! Published in 2018 at "Placenta"
DOI: 10.1016/j.placenta.2018.06.313
Abstract: INTRODUCTION Enhanced expression and activity of cyclooxygenase-2 (COX-2) has been reported in trophoblasts from women with preeclampsia compared with healthy pregnant women. Prostaglandin E2, the production of which is initiated by COX-2, and transforming growth… read more here.
Keywords: invasion; tgf; expression; cell invasion ... See more keywords
Avobenzone suppresses proliferative activity of human trophoblast cells and induces apoptosis mediated by mitochondrial disruption.
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2018.07.003
Abstract: Avobenzone is widely used in various personal care products, is present in swimming pools, and is toxic to aquatic organisms. However, it is unclear how avobenzone affects human trophoblast cells. Results of the present study… read more here.
Keywords: avobenzone; trophoblast cells; activity; human trophoblast ... See more keywords
Derivation of Human Trophoblast Stem Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cell stem cell"
DOI: 10.1016/j.stem.2017.11.004
Abstract: Trophoblast cells play an essential role in the interactions between the fetus and mother. Mouse trophoblast stem (TS) cells have been derived and used as the best in vitro model for molecular and functional analysis of… read more here.
Keywords: stem cells; human trophoblast; trophoblast; stem ... See more keywords
Cyclooxygenase (COX)-2 modulates Toxoplasma gondii infection, immune response and lipid droplets formation in human trophoblast cells and villous explants
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92120-3
Abstract: Congenital toxoplasmosis is represented by the transplacental passage of Toxoplasma gondii from the mother to the fetus. Our studies demonstrated that T. gondii developed mechanisms to evade of the host immune response, such as cyclooxygenase… read more here.
Keywords: trophoblast cells; cells villous; cox inhibitors; human trophoblast ... See more keywords
MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2105130118
Abstract: Significance The human placenta contains progenitors that give rise to highly specialized trophoblast cell types, and failures in their differentiation are associated with placental pathologies. Importantly, transcription factors controlling these cell fate decisions in humans… read more here.
Keywords: trophoblast stem; msx2; trophoblast; swi snf ... See more keywords
Tubulin detyrosination promotes human trophoblast syncytium formation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjz084
Abstract: Abstract Human trophoblast syncytialization is one of the most important yet least understood events during placental development. In this study, we found that detyrosinated α-tubulin (detyr-α-tub), which is negatively regulated by tubulin tyrosine ligase (TTL),… read more here.
Keywords: tubulin detyrosination; ttl; human trophoblast; trophoblast ... See more keywords
Anti-inflammatory effects of mesenchymal stem cell-derived exosomal microRNA-146a-5p and microRNA-548e-5p on human trophoblast cells.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaz054
Abstract: Human umbilical cord mesenchymal stem cells (MSCs) have been reported to improve the migration and invasion of trophoblast cells; however, little is known about whether MSC-derived exosomes and exosomal miRNAs can regulate trophoblast cell properties.… read more here.
Keywords: mir; trophoblast; microrna; trophoblast cells ... See more keywords
Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad109
Abstract: Endogenous retroviruses (ERVs) have been proposed as a driving force for the evolution of the mammalian placenta, however, the contribution of ERVs to placental development and the underlying regulatory mechanism remain largely elusive. A key… read more here.
Keywords: trophoblast syncytialization; human trophoblast; derived enhancers; placental development ... See more keywords
LMNA Determines Nuclear Morphology During Syncytialization of Human Trophoblast Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.836390
Abstract: Upon implantation, the trophectoderm differentiates into the multi-nucleated primitive syncytiotrophoblast (pSTB) through a process called primary syncytialization to facilitate maternal-fetal interactions and to establish a pregnancy. However, ethical issues and limited access to human embryos… read more here.
Keywords: stem cells; human trophoblast; trophoblast stem; syncytialization ... See more keywords