An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function
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DOI: 10.1080/15476286.2017.1377868
Abstract: ABSTRACT Tryptophanyl-tRNA synthetase (TrpRS) in vertebrates contains a N-terminal extension in front of the catalytic core. Proteolytic removal of the N-terminal 93 amino acids gives rise to T2-TrpRS, which has potent anti-angiogenic activity mediated through… read more here.
Keywords: zinc; trprs; human trprs; conformation ... See more keywords