Interaction of microtubule depolymerizing agent indanocine with different human αβ tubulin isotypes
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DOI: 10.1371/journal.pone.0194934
Abstract: Tubulin isotypes are known to regulate the stability and dynamics of microtubules, and are also involved in the development of resistance against microtubule-targeted cancer drugs. Indanocine, a potent microtubule depolymerizing agent, is highly active against… read more here.
Keywords: tubulin isotypes; depolymerizing agent; human tubulin; tubulin ... See more keywords
Modeling the Colchicum autumnale Tubulin and a Comparison of Its Interaction with Colchicine to Human Tubulin
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DOI: 10.3390/ijms18081676
Abstract: Tubulin is the target for many small-molecule natural compounds, which alter microtubules dynamics, and lead to cell cycle arrest and apoptosis. One of these compounds is colchicine, a plant alkaloid produced by Colchicum autumnale. While… read more here.
Keywords: modeling colchicum; colchicum autumnale; colchicine; autumnale tubulin ... See more keywords