YAF2 exerts anti-apoptotic effect in human tumor cells in a FANK1- and phosphorylation-dependent manner.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.03.105
Abstract: YY1-associated factor 2 (YAF2) was frequently reported to modulate target gene transcription through both epigenetic and non-epigenetic means. However, other mechanisms were also utilized by YAF2 to carry out its biological functions. Here, we demonstrated… read more here.
Keywords: phosphorylated yaf2; dependent manner; tumor cells; human tumor ... See more keywords
Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.07.013
Abstract: Cancer elimination in humans can be achieved with immunotherapy that relies on T lymphocyte-mediated recognition of tumor antigens. Several types of these antigens have been recognized based on their cellular origins and expression patterns, while… read more here.
Keywords: immunotherapy; tumor antigens; identifying targeting; human tumor ... See more keywords
Covalent Conjugate of Ser-Pro-Cys Tripeptide with PEGylated Comb-Like Polymer as Novel Killer of Human Tumor Cells
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03611
Abstract: Recently, we detected a previously unknown Ser-Pro-Cys (SPC) tripeptide in the blood serum of multiple sclerosis patients. Its role as a biomarker of the autoimmune disease was suggested, although its origin and real biological activity… read more here.
Keywords: human tumor; polymer; comb like; tumor cells ... See more keywords
IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-54420-w
Abstract: Blockade of NKG2A/HLA-E interaction is a promising strategy to unleash the anti-tumor response. Yet the role of NKG2A+ CD8 T cells in the anti-tumor response and the regulation of NKG2A expression on human tumor-infiltrating T… read more here.
Keywords: cd8 cells; human tumor; tumor; reactive cd8 ... See more keywords
The new microbiome on the block: challenges and opportunities of using human tumor sequencing data to study microbes
Sign Up to like & getrecommendations! Published in 2025 at "Nature Methods"
DOI: 10.1038/s41592-025-02807-y
Abstract: Microbes within tumors have been recognized and experimentally related to oncogenesis, tumor growth, metastasis and therapeutic responsiveness. Studying the tumor microbiome presents difficulties, as early indications suggest that microbe populations are low in abundance, sparse… read more here.
Keywords: new microbiome; human tumor; tumor; sequencing data ... See more keywords
Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004268
Abstract: Background Dendritic cells (DCs) are professional antigen presenting cells that initiate immune defense to pathogens and tumor cells. Human tumors contain only few DCs that mostly display a non-activated phenotype. Hence, activation of tumor-associated DCs… read more here.
Keywords: human tumor; tl8 506; cdcs; blood ... See more keywords
Postneonatal Mortality and Liver Changes in Cloned Pigs Associated with Human Tumor Necrosis Factor Receptor I-Fc and Human Heme Oxygenase-1 Overexpression
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/5276576
Abstract: Soluble human tumor necrosis factor (shTNFRI-Fc) and human heme oxygenase 1 (hHO-1) are key regulators for protection against oxidative and inflammatory injury for xenotransplantation. Somatic cells with more than 10 copy numbers of shTNFRI-Fc and… read more here.
Keywords: human heme; liver; heme oxygenase; tumor necrosis ... See more keywords
Abstract 5097: Knock-in of a human tumor suppressor (25-kilobase pairs) by traditional and CRISPR/Cas9-stimulated homologous recombination
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5097
Abstract: Here we describe an expansion of the DNA size limitations associated with CRISPR knock-in technology, more specifically, the physical extent to which mouse genomic DNA can be replaced with donor (in this case, human) DNA… read more here.
Keywords: tumor suppressor; human tumor; knock human; tumor ... See more keywords
Abstract 3707: 2D organoid (2DO) as human tumor model for predicting therapeutic effect of anti-cancer drugs
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-3707
Abstract: Primary cultured cells derived from an individual patient’s tumor have phenotypic heterogeneity unlike established cancer cell lines. We established organoid in two-dimensional (2D) culture with the reproducibility of clinical phenotypic heterogeneity as a human tumor… read more here.
Keywords: human tumor; cancer; tumor model; tumor ... See more keywords
Abstract 2769: Qualification of human tumor cell lines for inclusion in the OncoPanel™ cell-based profiling and screening service
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2769
Abstract: It is estimated that in the U.S. alone, roughly $200 billion are spent each year on cancer drug discovery. Although this spending is significant, we have still to find truly resilient and enduring treatment plans… read more here.
Keywords: cell; human tumor; tumor cell; cell lines ... See more keywords
Abstract 4910: Human tumor primary culture analyses for the prediction of response to chemotherapy, targeted agents, drug combinations and metabolic inhibitors: The role of ex vivo analysis of programmed cell death in cancer therapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4910
Abstract: There is growing interest in the use of human tumor primary cultures for the prediction of response to drugs and drug combinations in cancer medicine. While the field has witnessed numerous attempts to apply human… read more here.
Keywords: cell; human tumor; tumor; drug ... See more keywords