LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "human tumors" as a keyword



A comprehensive analysis of the relationship between inflammasomes and autophagy in human tumors: Recent developments

Sign Up to like & get
recommendations! Published in 2025 at "Journal of Cell Communication and Signaling"

DOI: 10.1002/ccs3.70035

Abstract: Autophagy and inflammasomes are essential cellular mechanisms that maintain homeostasis, regulate immune responses, and influence disease progression, especially in cancer. Autophagy, a lysosome‐mediated process, removes damaged organelles and misfolded proteins, allowing cells to adapt to… read more here.

Keywords: autophagy human; human tumors; inflammasomes autophagy; analysis relationship ... See more keywords

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors.

Sign Up to like & get
recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.09.082

Abstract: The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate transcription and promote oncogenic pathways. Here, we designed an algorithmic approach (RESET) to identify aberrant DNA methylation and… read more here.

Keywords: dna; aberrant dna; human tumors; cancer ... See more keywords
Photo by museumsvictoria from unsplash

Analysis of somatic microsatellite indels identifies driver events in human tumors

Sign Up to like & get
recommendations! Published in 2017 at "Nature Biotechnology"

DOI: 10.1038/nbt.3966

Abstract: Microsatellites (MSs) are tracts of variable-length repeats of short DNA motifs that exhibit high rates of mutation in the form of insertions or deletions (indels) of the repeated motif. Despite their prevalence, the contribution of… read more here.

Keywords: somatic microsatellite; microsatellite indels; human tumors; cancer ... See more keywords
Photo from academic.microsoft.com

Transposase-driven rearrangements in human tumors

Sign Up to like & get
recommendations! Published in 2017 at "Nature Genetics"

DOI: 10.1038/ng.3908

Abstract: A new study shows that aberrant DNA transposase activity promotes structural alterations that are clonally selected to drive tumor development. This discovery uncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to… read more here.

Keywords: human tumors; rearrangements human; transposase driven; driven rearrangements ... See more keywords

A Pan-Cancer Analysis of the Role of PBRM1 in Human Tumors

Sign Up to like & get
recommendations! Published in 2022 at "Stem Cells International"

DOI: 10.1155/2022/7676541

Abstract: To understand common but distinctive systems to drive oncogenic stages in human tumors is critical for understanding disease programme and developing novel therapeutic strategies. PBRM1 is a critical gene in oncogenesis. We found that PBRM1… read more here.

Keywords: hnsc kirc; human tumors; pan cancer; analysis ... See more keywords

Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors

Sign Up to like & get
recommendations! Published in 2020 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-20-0778

Abstract: Purpose: Immune checkpoint blockade has shown remarkable efficacy, but in only a minority of patients with cancer, suggesting the need to develop additional treatment strategies. Aberrant glycosylation in tumors, resulting from the dysregulated expression of… read more here.

Keywords: immune response; human tumors; treatment; man2a1 ... See more keywords

Under (Genetic Selection) Pressure: Human Tumors and Human Populations in Hypoxia.

Sign Up to like & get
recommendations! Published in 2025 at "Cancer discovery"

DOI: 10.1158/2159-8290.cd-25-0175

Abstract: Arenillas and colleagues report that pheochromocytomas and paragangliomas in the setting of chronic hypoxia due to cyanotic congenital heart disease harbor, at high frequency, somatic gain-of-function mutations in the EPAS1 gene, which encodes for one… read more here.

Keywords: genetic selection; human tumors; human populations; pressure human ... See more keywords

Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance.

Sign Up to like & get
recommendations! Published in 2017 at "Cancer immunology research"

DOI: 10.1158/2326-6066.cir-16-0400

Abstract: Tumors use various mechanisms to avoid immune destruction. Cyclooxygenase-2 (COX-2) expression may be a driver of immune suppression in melanoma, but the mechanisms involved remain elusive. Here, we show that COX-2 expression drives constitutive expression… read more here.

Keywords: expression human; ido1 expression; constitutive ido1; expression ... See more keywords
Photo from wikipedia

The role of KMT2 gene in human tumors.

Sign Up to like & get
recommendations! Published in 2022 at "Histology and histopathology"

DOI: 10.14670/hh-18-447

Abstract: Histone methylation plays a crucial role in the regulation of gene transcriptional expression, and aberration of methylation-modifying enzyme genes can lead to a variety of genetic diseases, including human cancers. The histone modified protein KMT2… read more here.

Keywords: human tumors; gene human; kmt2 gene; role kmt2 ... See more keywords
Photo by alinabelogolova from unsplash

Critical Roles of PIWIL1 in Human Tumors: Expression, Functions, Mechanisms, and Potential Clinical Implications

Sign Up to like & get
recommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.656993

Abstract: P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a class of small non-coding RNA molecules that are 24–31 nucleotides in length. PiRNAs are thought to bind to PIWI proteins (PIWL1-4, a subfamily of Argonaute proteins), forming… read more here.

Keywords: piwi proteins; potential clinical; piwil1 human; human tumors ... See more keywords

Roles of Toll-Like Receptor 3 in Human Tumors

Sign Up to like & get
recommendations! Published in 2021 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2021.667454

Abstract: Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded RNA and induce activation of NF-κB and the production of… read more here.

Keywords: toll like; receptor human; like receptor; human tumors ... See more keywords