Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.09.082
Abstract: The discovery of cancer-associated alterations has primarily focused on genetic variants. Nonetheless, altered epigenomes contribute to deregulate transcription and promote oncogenic pathways. Here, we designed an algorithmic approach (RESET) to identify aberrant DNA methylation and… read more here.
Keywords: dna; aberrant dna; human tumors; cancer ... See more keywords
Analysis of somatic microsatellite indels identifies driver events in human tumors
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt.3966
Abstract: Microsatellites (MSs) are tracts of variable-length repeats of short DNA motifs that exhibit high rates of mutation in the form of insertions or deletions (indels) of the repeated motif. Despite their prevalence, the contribution of… read more here.
Keywords: somatic microsatellite; microsatellite indels; human tumors; cancer ... See more keywords
Transposase-driven rearrangements in human tumors
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3908
Abstract: A new study shows that aberrant DNA transposase activity promotes structural alterations that are clonally selected to drive tumor development. This discovery uncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to… read more here.
Keywords: human tumors; rearrangements human; transposase driven; driven rearrangements ... See more keywords
A Pan-Cancer Analysis of the Role of PBRM1 in Human Tumors
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells International"
DOI: 10.1155/2022/7676541
Abstract: To understand common but distinctive systems to drive oncogenic stages in human tumors is critical for understanding disease programme and developing novel therapeutic strategies. PBRM1 is a critical gene in oncogenesis. We found that PBRM1… read more here.
Keywords: hnsc kirc; human tumors; pan cancer; analysis ... See more keywords
Inhibition of MAN2A1 Enhances the Immune Response to Anti–PD-L1 in Human Tumors
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-20-0778
Abstract: Purpose: Immune checkpoint blockade has shown remarkable efficacy, but in only a minority of patients with cancer, suggesting the need to develop additional treatment strategies. Aberrant glycosylation in tumors, resulting from the dysregulated expression of… read more here.
Keywords: immune response; human tumors; treatment; man2a1 ... See more keywords
Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-16-0400
Abstract: Tumors use various mechanisms to avoid immune destruction. Cyclooxygenase-2 (COX-2) expression may be a driver of immune suppression in melanoma, but the mechanisms involved remain elusive. Here, we show that COX-2 expression drives constitutive expression… read more here.
Keywords: expression human; ido1 expression; constitutive ido1; expression ... See more keywords
The role of KMT2 gene in human tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Histology and histopathology"
DOI: 10.14670/hh-18-447
Abstract: Histone methylation plays a crucial role in the regulation of gene transcriptional expression, and aberration of methylation-modifying enzyme genes can lead to a variety of genetic diseases, including human cancers. The histone modified protein KMT2… read more here.
Keywords: human tumors; gene human; kmt2 gene; role kmt2 ... See more keywords
Critical Roles of PIWIL1 in Human Tumors: Expression, Functions, Mechanisms, and Potential Clinical Implications
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.656993
Abstract: P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a class of small non-coding RNA molecules that are 24–31 nucleotides in length. PiRNAs are thought to bind to PIWI proteins (PIWL1-4, a subfamily of Argonaute proteins), forming… read more here.
Keywords: piwi proteins; potential clinical; piwil1 human; human tumors ... See more keywords
Roles of Toll-Like Receptor 3 in Human Tumors
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.667454
Abstract: Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded RNA and induce activation of NF-κB and the production of… read more here.
Keywords: toll like; receptor human; like receptor; human tumors ... See more keywords
Characterizing the role of SLC3A2 in the molecular landscape and immune microenvironment across human tumors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.961410
Abstract: Background: Inducing ferroptosis in human tumors has become a potential strategy to improve the prognosis of patients, even in those with chemotherapeutic resistance. The xCT complex is a major target for ferroptosis induction, constituted by… read more here.
Keywords: role; immune microenvironment; human tumors; role slc3a2 ... See more keywords
The oncogenic role of SNRPB in human tumors: A pan-cancer analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.994440
Abstract: Purpose: The purpose of this study was to explore the oncogenic role of small nuclear ribonucleoprotein polypeptides B and B1 (SNRPB) in human tumors. Materials and methods: Study cases were acquired from The Cancer Genome… read more here.
Keywords: role; human tumors; snrpb human; expression ... See more keywords