Interactions of Phenylalanine Derivatives with Human Tyrosinase: Lessons from Experimental and Theoretical tudies
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DOI: 10.1002/cbic.202400235
Abstract: The pigmentation of the skin, modulated by different actors in melanogenesis, is mainly due to the melanins (protective pigments). In humans, these pigments’ precursors are synthetized by an enzyme known as tyrosinase (TyH). The regulation… read more here.
Keywords: interactions phenylalanine; tyrosinase; derivatives human; phenylalanine derivatives ... See more keywords
Advances in the Design of Genuine Human Tyrosinase Inhibitors for Targeting Melanogenesis and Related Pigmentations.
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DOI: 10.1021/acs.jmedchem.0c00994
Abstract: Human tyrosinase (hsTYR) is the key enzyme ensuring the conversion of L-tyrosine to dopaqui-none, thereby initiating melanin synthesis, i.e. melanogenesis. Although the protein has long been familiar, knowledge about its three-dimensional structure and efficient overexpression… read more here.
Keywords: tyrosinase inhibitors; chemistry; tyrosinase; advances design ... See more keywords
Does trigonelline help skin tone? Molecular docking studies of trigonelline on the human tyrosinase, formulation, optimization, and characterization of an emulgel‐containing Trigonella foenum‐graecum L. fenugreek standardized hydroalcoholic extract
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DOI: 10.1111/jocd.15453
Abstract: This study aimed to perform molecular docking studies to identify possibilities of the inhibitory potential of the trigonelline present in fenugreek seeds on the human tyrosinase, standardize fenugreek extract, formulate, and characterize an emulgel‐containing fenugreek… read more here.
Keywords: molecular docking; human tyrosinase; trigonelline; docking studies ... See more keywords
KT‐939: A Next‐Generation Human Tyrosinase Inhibitor With Superior Efficacy for the Safe Management of Hyperpigmentation
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DOI: 10.1111/jocd.70510
Abstract: Tyrosinase is the rate‐limiting enzyme in melanin biosynthesis, and its overactivity contributes to hyperpigmentation disorders. Existing tyrosinase inhibitors are often limited by poor potency against human tyrosinase (hTYR) or safety concerns. read more here.
Keywords: hyperpigmentation; tyrosinase; 939 next; next generation ... See more keywords
Enhancing Catecholase Activity of a Recombinant Human Tyrosinase Through Multiple Strategies
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DOI: 10.30498/ijb.2020.137293.2310
Abstract: Background: Tyrosinases are copper-containing enzymes that initiate the melanin synthesis. They catalyze the direct oxidation of L-tyrosine or L-DOPA into L-DOPAquinone. Objectives: In present study, we aimed to obtain a recombinant tyrosinase with enhanced catecholase… read more here.
Keywords: catecholase; activity recombinant; catecholase activity; human tyrosinase ... See more keywords
Isolation and Biological Evaluation of Human Tyrosinase Inhibitors from the Fruit of Xanthium strumarium L.
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DOI: 10.3390/molecules30183689
Abstract: Tyrosinase catalyzes the rate-limiting steps of melanin production, posing as an important target for treating skin pigmentation. This study investigates bioactive human tyrosinase inhibitors from Xanthium strumarium L. using a combined strategy of cell lysate,… read more here.
Keywords: tyrosinase; xanthium strumarium; tyrosinase inhibitors; human tyrosinase ... See more keywords