Metabolic Profile of Etomidate and Its Three Analogs in Zebrafish, Human Liver Microsomes, Human Urine and Hair Samples Using UHPLC-Q Exactive Orbitrap-HRMS.
Sign Up to like & getrecommendations! Published in 2025 at "Drug testing and analysis"
DOI: 10.1002/dta.3869
Abstract: Etomidate is a short-acting non-barbiturate imidazole used as an intravenous anesthetic agent in humans, while metomidate and propoxate are common anesthetic drug for fishes. Today, etomidate, and its analogs, including isopropoxate, are increasingly abused, leading… read more here.
Keywords: human urine; analogs zebrafish; liver microsomes; human liver ... See more keywords
Comparison of 1D a 2D ITP-MS performance parameters and application possibilities: ultratrace determination of B vitamins in human urine.
Sign Up to like & getrecommendations! Published in 2021 at "Electrophoresis"
DOI: 10.1002/elps.202100209
Abstract: A possibility to investigate analytes at ultra-low concentration levels still remains a hot topic in bioanalysis. In this area various preconcentration techniques are an integral part of analytical procedures. When applying electromigration separation techniques, an… read more here.
Keywords: human urine; itp method; performance parameters; itp ... See more keywords
Inducing differentiation of human urine‐derived stem cells into hepatocyte‐like cells by coculturing with human hepatocyte L02 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29301
Abstract: To investigate the possibility of inducing differentiation of human urine‐derived stem cells (hUSCs) into hepatocyte‐like cells by coculturing with human hepatocyte L02 cells in vitro. read more here.
Keywords: human urine; inducing differentiation; differentiation human; derived stem ... See more keywords
Dispersive liquid-liquid microextraction as an effective preanalytical step for the determination of estradiol in human urine.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of separation science"
DOI: 10.1002/jssc.201700123
Abstract: In this work, a fast and effective dispersive liquid-liquid microextraction was developed for the isolation and preconcentration of free 17 β-estradiol, the main human estrogen, from real human urine samples. To optimize the extraction technique, few… read more here.
Keywords: human urine; extraction; liquid; dispersive liquid ... See more keywords
Accurate and sensitive determination of sildenafil, tadalafil, vardenafil, and avanafil in illicit erectile dysfunction medications and human urine by LC with quadrupole-TOF-MS/MS and their behaviors in simulated gastric conditions.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of separation science"
DOI: 10.1002/jssc.201800734
Abstract: The widespread use of phosphodiesterase-5 inhibitors has attracted broad attention of counterfeiters to develop illicit erectile products with inaccurate amounts, unknown toxicity, and purity of active ingredients. Correspondingly, intake of these products endangers consumer health… read more here.
Keywords: human urine; medications human; determination; gastric conditions ... See more keywords
Separation and identification of cetirizine enantiomers in human urine by CE and circular dichroism independent of their standards.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of separation science"
DOI: 10.1002/jssc.202200901
Abstract: Enantioseparation and determination of chiral drugs are of vital importance in biochemical and pharmaceutical research, due to the different biological activity, mechanism, and toxicity of individual enantiomers. As a second-generation H(1)-antagonist, cetirizine's pharmaceutical activity is… read more here.
Keywords: human urine; cetirizine enantiomers; identification; dichroism ... See more keywords
Influence of vitamins and food on the fluorescence spectrum of human urine
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DOI: 10.1002/lsm.23785
Abstract: Fluorescence spectroscopy of human urine is a method with the potential to gain importance as a diagnostic tool in the medical field, e.g., for measuring Coproporphyrin III (CPIII) as an indicator of cancer and acute… read more here.
Keywords: human urine; food; fluorescence; influence ... See more keywords
Flow injection tyrosinase biosensor for direct determination of acetaminophen in human urine
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-01687-4
Abstract: AbstractAn amperometric biosensor compatible with a flow injection analysis (FIA) for highly selective determination of acetaminophen (APAP) in a sample of human urine was developed. This biosensor is also suitable for use in the routine… read more here.
Keywords: determination acetaminophen; human urine; biosensor; determination ... See more keywords
Determination of cocaine adulterants in human urine by dispersive liquid-liquid microextraction and high-performance liquid chromatography
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-01797-z
Abstract: This study aimed to determine simultaneously five major street cocaine adulterants (caffeine, lidocaine, phenacetin, diltiazem, and hydroxyzine) in human urine by dispersive liquid-liquid microextraction (DLLME) and high-performance liquid chromatography. The chromatographic separation was obtained in… read more here.
Keywords: human urine; liquid; dispersive liquid; cocaine adulterants ... See more keywords
Comparison of three electromembrane-based extraction systems for NSAIDs analysis in human urine samples
Sign Up to like & getrecommendations! Published in 2020 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-020-02804-4
Abstract: A comparative study on the extraction efficiency of five non-steroidal anti-inflammatories was carried out using three different electromembrane extraction (EME) devices with different geometries. The employed setups were (a) a hollow fiber configuration (HF-EME), (b)… read more here.
Keywords: human urine; extraction; eme; comparison three ... See more keywords
Comparative evaluation of comprehensive offline 2D-LC strategies coupled to MS for untargeted metabolomic studies of human urine
Sign Up to like & getrecommendations! Published in 2025 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-025-06195-2
Abstract: Out of the broad selection of analytical methods applied in metabolomic studies, liquid chromatography coupled to mass spectrometry (LC-MS) has the highest coverage potential. In that regard, the quality of the separation process is crucial… read more here.
Keywords: human urine; untargeted metabolomic; offline; metabolomic studies ... See more keywords