Mechanobiological Adaptation to Hyperosmolarity Enhances Barrier Function in Human Vascular Microphysiological System (Adv. Sci. 13/2023)
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206384
Abstract: In infectious disease such as sepsis and COVID‐19, blood vessel leakage treatment is critical to prevent fatal progression into multi‐organ failure and ultimately death, but the existing effective therapeutic modalities that improve vascular barrier function… read more here.
Keywords: barrier function; human vascular; function; vascular microphysiological ... See more keywords
Human vascular cell responses to the circulating bone hormone osteocalcin
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28707
Abstract: The purpose of this study was to characterize the direct effects of uncarboxylated osteocalcin (ucOCN) on vascular cell biology in vitro, to assess its potential function in pathophysiological conditions such as atherosclerosis. Human aortic endothelial… read more here.
Keywords: cell responses; human vascular; vascular cell; cell ... See more keywords
Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells
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DOI: 10.1007/s00011-018-1178-z
Abstract: ObjectiveIL-1β secretion by the inflammasome is strictly controlled and requires two sequential signals: a priming signal and an activating signal. Lysosomal membrane permeabilization (LMP) plays a critical role in the regulation of NLRP3 inflammasome, and… read more here.
Keywords: secretion; vascular smooth; human vascular; lysosomal membrane ... See more keywords
Rapid transient expression of functional human vascular endothelial growth factor in Nicotiana benthamiana and characterization of its biological activity
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DOI: 10.1016/j.btre.2020.e00514
Abstract: Highlights • Growth factors play a crucial role in wound healing.• Plant-produced human vascular endothelial growth factor (hVEGF) induces the keratinocyte cells migration.• The plant-produced hVEGF has shown potential as a wound healing agent in… read more here.
Keywords: vascular endothelial; endothelial growth; human vascular; growth factor ... See more keywords
Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials.
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DOI: 10.1016/j.clnu.2016.11.013
Abstract: BACKGROUND & AIMS Polyphenol intake has been linked to improvements in human vascular function, although data on hydroxycinnamates, such as chlorogenic acid (CGA) have not yet been studied. We aimed to investigate the impact of… read more here.
Keywords: intervention; vascular function; cga; human vascular ... See more keywords
Effects of novel brominated flame retardant TBPH and its metabolite TBMEHP on human vascular endothelial cells: Implication for human health risks
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Research"
DOI: 10.1016/j.envres.2017.02.028
Abstract: ABSTRACT As a replacement for polybrominated diphenyl ethers, bis‐(2‐ethylhexyl) tetrabromophthalate (TBPH) is widely used as a novel flame retardant and has been detected in many environmental matrix including human blood. TBPH can be metabolized into… read more here.
Keywords: flame retardant; vascular endothelial; tbmehp; human vascular ... See more keywords
An in vivo model allowing continuous observation of human vascular formation in the same animal over time
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DOI: 10.1038/s41598-020-80497-6
Abstract: Angiogenesis contributes to numerous pathological conditions. Understanding the molecular mechanisms of angiogenesis will offer new therapeutic opportunities. Several experimental in vivo models that better represent the pathological conditions have been generated for this purpose in… read more here.
Keywords: formation; human blood; human vascular; continuous observation ... See more keywords
Characterisation of P2Y2 receptors in human vascular endothelial cells using AR‐C118925XX, a competitive and selective P2Y2 antagonist
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DOI: 10.1111/bph.14715
Abstract: There is a lack of potent, selective antagonists at most subtypes of P2Y receptor. The aims of this study were to characterise the pharmacological properties of the proposed P2Y2 receptor antagonist, AR‐C118925XX, and then to… read more here.
Keywords: p2y2 receptors; vascular endothelial; human vascular; endothelial cells ... See more keywords