Purkinje network and myocardial substrate at the onset of human ventricular fibrillation: implications for catheter ablation
Sign Up to like & getrecommendations! Published in 2022 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehab893
Abstract: Abstract Aims Mapping data of human ventricular fibrillation (VF) are limited. We performed detailed mapping of the activities underlying the onset of VF and targeted ablation in patients with structural cardiac abnormalities. Methods and results… read more here.
Keywords: ventricular fibrillation; ablation; purkinje; substrate ... See more keywords
Prediction of the mechanical response of cardiac alternans by using an electromechanical model of human ventricular myocytes
Sign Up to like & getrecommendations! Published in 2019 at "BioMedical Engineering OnLine"
DOI: 10.1186/s12938-019-0690-x
Abstract: PurposeAlthough the quantitative analysis of electromechanical alternans is important, previous studies have focused on electrical alternans, and there is a lack quantitative analysis of mechanical alternans at the subcellular level according to various basic cycle… read more here.
Keywords: model human; ventricular myocytes; tension; human ventricular ... See more keywords
Action Potential Recording and Pro-arrhythmia Risk Analysis in Human Ventricular Trabeculae
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2017.01109
Abstract: To assess drug-induced pro-arrhythmic risk, especially Torsades de Pointe (TdP), new models have been proposed, such as in-silico modeling of ventricular action potential (AP) and stem cell-derived cardiomyocytes (SC-CMs). Previously we evaluated the electrophysiological profile… read more here.
Keywords: pro arrhythmic; risk; drug; ventricular trabeculae ... See more keywords
A Novel In Silico Electromechanical Model of Human Ventricular Cardiomyocyte
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.906146
Abstract: Contractility has become one of the main readouts in computational and experimental studies on cardiomyocytes. Following this trend, we propose a novel mathematical model of human ventricular cardiomyocytes electromechanics, BPSLand, by coupling a recent human… read more here.
Keywords: electromechanical model; novel silico; silico electromechanical; model human ... See more keywords
Grapefruit Flavonoid Naringenin Sex-Dependently Modulates Action Potential in an In Silico Human Ventricular Cardiomyocyte Model
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11091672
Abstract: Recent in vitro studies showed that grapefruit (Citrus × paradisi) flavonoid naringenin alters the function of cardiac ion channels. Here, we explored the effect of naringenin on cardiomyocyte action potentials (APs) using a detailed in… read more here.
Keywords: flavonoid naringenin; naringenin; cardiomyocyte; sex ... See more keywords
Acetylcholine Reduces IKr and Prolongs Action Potentials in Human Ventricular Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020244
Abstract: Vagal nerve stimulation (VNS) has a meaningful basis as a potentially effective treatment for heart failure with reduced ejection fraction. There is an ongoing VNS randomized study, and four studies are completed. However, relatively little… read more here.
Keywords: ventricular cardiomyocytes; effect; action potential; action ... See more keywords