Organotypic human ex vivo models for coronavirus disease 2019 research and drug development
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2021.04.006
Abstract: Since the discovery of SARS-CoV-2 in late 2019, intense research efforts on an unprecedented scale have focused on the study of viral entry mechanisms and adaptive immunity. While the identification of ACE2 and other co-receptors… read more here.
Keywords: research; organotypic human; drug; human vivo ... See more keywords
[OA019] Human in-vivo Magnetic Resonance Current Density Imaging (MRCDI) and MR Electrical Impedance Tomography (MREIT)
Sign Up to like & getrecommendations! Published in 2018 at "Physica Medica"
DOI: 10.1016/j.ejmp.2018.06.091
Abstract: Purpose Information on the electrical tissue conductivity might be useful for the diagnosis and characterization of pathologies such as tumors [1] . MRCDI and MREIT are two emerging non-invasive techniques for imaging of weak currents… read more here.
Keywords: mreit; vivo magnetic; current flow; oa019 human ... See more keywords
Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20464-4
Abstract: The release of aromatic amines from drugs and other xenobiotics resulting from the hydrolysis of metabolically labile amide bonds presents a safety risk through several mechanisms, including geno-, hepato- and nephrotoxicity. Whilst multiple in vitro… read more here.
Keywords: vitro systems; minipig human; hydrolysis; human vivo ... See more keywords
First Human In Vivo Neuroelectrophysiology Recordings of Uncrossed Dentatothalamocortical White-Matter Connections
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200990
Abstract: Objectives We aim to demonstrate intraoperative recording of cerebellar to cortical pathways that have not been previously recorded in humans, though imaged. Methods We report 2 cases with intraoperative neurophysiologic mapping of cerebellocortical tracts. Direct… read more here.
Keywords: human vivo; motor; dentate nucleus; uncrossed dentatothalamocortical ... See more keywords
Pharmacologic Targeting of MMP2/9 Decreases Peritoneal Metastasis Formation of Colorectal Cancer in a Human Ex Vivo Peritoneum Culture Model
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14153760
Abstract: Simple Summary We investigated the effects of matrix metalloproteinases (MMPs) on the peritoneal attachment of colorectal cancer cells in patient samples and in a human ex vivo peritoneum model. MMP2/9 overexpression and enhanced fibronectin cleavage… read more here.
Keywords: colonisation; human vivo; mmp2; colorectal cancer ... See more keywords