Cholesterol inhibits human voltage-gated proton channel hHv1
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205420119
Abstract: Significance Our work identified membrane cholesterol as a new inhibitor of human voltage-gated proton channel hHv1. Using single-molecule fluorescence resonance energy transfer (smFRET), we further showed that cholesterol inhibits the hHv1 channel by stabilizing the… read more here.
Keywords: human voltage; voltage gated; proton channel; cholesterol ... See more keywords
Quantitative insights into the mechanism of proton conduction and selectivity for the human voltage-gated proton channel Hv1
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2407479121
Abstract: Significance The almost perfect proton selectivity of the human voltage-gated proton (hHv1) channels is a long-standing mystery. The extensive multiscale simulations in this paper offer quantitative insight into the mechanism behind the selective proton transport… read more here.
Keywords: proton; selectivity human; human voltage; voltage gated ... See more keywords
The Molecular Mechanism of Human Voltage-Dependent Anion Channel 1 Blockade by the Metallofullerenol Gd@C82(OH)22: An In Silico Study
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DOI: 10.3390/biom12010123
Abstract: The endohedral metallofullerenol Gd@C82(OH)22 has been identified as a possible antineoplastic agent that can inhibit both the growth and metastasis of cancer cells. Despite these potentially important effects, our understanding of the interactions between Gd@C82(OH)22… read more here.
Keywords: human voltage; anion channel; c82; dependent anion ... See more keywords