Optimized copolymeric microstructured platforms for smart controlled delivery of an anticoagulant drug: preparation, in vitro assessment and crossover study in healthy adult human volunteers.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.121084
Abstract: In the present study, novel micro-structured copolymeric carriers were developed based on the grafting technology where acrylamide was chemically crosslinked with different types of Eudragits® (NE30D, L100, RL30D, or RS30D) based on a 41*21 factorial… read more here.
Keywords: human volunteers; formulation; study; anticoagulant drug ... See more keywords
Assessment of Diet-Related Changes on Albendazole Absorption, Systemic Exposure, and Pattern of Urinary Excretion in Treated Human Volunteers
Sign Up to like & getrecommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00432-21
Abstract: Soil-transmitted-helminth (STH) infections are a persistent global public health problem. Control strategies for STH have been based on the use of mass drug administration (MDA) mainly targeting preschool- and school-aged-children, although there is increasing interest… read more here.
Keywords: treated human; drug; treatment; alb treatment ... See more keywords
Comparative metabolism and tolerability of racemic primaquine and its enantiomers in human volunteers during 7-day administration
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1104735
Abstract: Primaquine (PQ) is an 8-aminoquinoline antimalarial, active against dormant Plasmodium vivax hypnozoites and P. falciparum mature gametocytes. PQ is currently used for P. vivax radical cure and prevention of malaria transmission. PQ is a racemic… read more here.
Keywords: primaquine; metabolism; pharmacology; tolerability ... See more keywords
Studies on the Reaction of Dietary Methylglyoxal and Creatine during Simulated Gastrointestinal Digestion and in Human Volunteers
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DOI: 10.3390/nu14173598
Abstract: The reactive 1,2-dicarbonyl compound methylglyoxal (MGO) is consumed with food and its concentrations decrease during digestion. In the present paper, the reaction of MGO with creatine, arginine, and lysine during simulated digestion, and its reaction… read more here.
Keywords: digestion human; creatine; methylglyoxal; human volunteers ... See more keywords