Analgesia and Humane Endpoints for Rodents in Sepsis Research.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1488-4_19
Abstract: Numerous regulatory bodies around the world require analgesics for rodents undergoing surgery to induce sepsis. Well-controlled pain will decrease morbidity. Options for analgesics include NSAIDs, local analgesics, and opioids. Supportive care can also decrease stress… read more here.
Keywords: endpoints rodents; rodents sepsis; biology; sepsis research ... See more keywords
Humane Intervention Points: Refining endpoint terminology to incorporate non-euthanasia intervention options to improve animal welfare and preserve experimental outcomes
Sign Up to like & getrecommendations! Published in 2022 at "Laboratory Animals"
DOI: 10.1177/00236772221090801
Abstract: Consideration of The Three R’s (Replacement, Reduction, and Refinement) is essential when setting Humane Endpoints; however, a common interpretation assumes that Humane Endpoints are timepoints to perform euthanasia. This interpretation is not always consistent with… read more here.
Keywords: humane endpoints; humane intervention; intervention options; intervention ... See more keywords