Effects of SA237, a humanized anti-interleukin-6 receptor monoclonal antibody, on pre- and postnatal development in cynomolgus monkey.
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DOI: 10.1002/bdr2.1036
Abstract: BACKGROUND SA237 is a humanized anti-interleukin-6 receptor (IL-6R) monoclonal antibody in which the constant and variable regions have been engineered for a longer plasma half-life. According to literature, blocking of IL-6 related functions could have… read more here.
Keywords: humanized anti; antibody; sa237 humanized; postnatal development ... See more keywords
A mathematical model of a recombinant humanized anti‐cocaine monoclonal antibody’s effects on cocaine pharmacokinetics in mice
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DOI: 10.1016/j.lfs.2017.07.006
Abstract: Aims A recombinant humanized anti‐cocaine monoclonal antibody (mAb), h2E2, is at an advanced stage of pre‐clinical development as an immunotherapy for cocaine abuse. It is hypothesized that h2E2 binds to and sequesters cocaine in the… read more here.
Keywords: humanized anti; antibody; model; recombinant humanized ... See more keywords
A Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumors
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DOI: 10.1080/19420862.2020.1773751
Abstract: ABSTRACT Hu14.18K322A is a humanized anti-GD2 monoclonal antibody with a single point mutation that reduces complement-mediated cytotoxicity, with a maximum tolerated dose (MTD) of 60 mg/m2 daily for 4 days in children with recurrent/refractory neuroblastoma.… read more here.
Keywords: humanized anti; anti gd2; schedule; patients osteosarcoma ... See more keywords
Abstract 540: AO-176, a normal cell sparing humanized anti-CD47 antibody
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DOI: 10.1158/1538-7445.sabcs18-540
Abstract: AO-176 is a next generation humanized anti-CD47 IgG2 that binds human and cynomolgus monkey CD47 equivalently. AO-176, like other CD47 antibodies, blocks the interaction of CD47 with SIRPα, inducing phagocytosis of tumor cells by activated… read more here.
Keywords: toxicology; anti cd47; cd47; tumor ... See more keywords
A Novel Humanized Anti-Interleukin-6 Antibody HZ0408b With Anti-Rheumatoid Arthritis Therapeutic Potential
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DOI: 10.3389/fimmu.2021.816646
Abstract: Interleukin-6 (IL-6), a pleiotropic cytokine that regulates immune responses and inflammatory reactions, plays a pivotal role in the development of rheumatoid arthritis (RA). Blockade of IL-6 signaling with the monoclonal antibody (mAb) represents an important… read more here.
Keywords: mab; humanized anti; novel humanized; rheumatoid arthritis ... See more keywords