The metabolic fate of fenclozic acid in chimeric mice with a humanized liver
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2274-0
Abstract: The metabolic fate of the human hepatotoxin fenclozic acid ([2-(4-chlorophenyl)-1,3-thiazol-4-yl]acetic acid) (Myalex) was studied in normal and bile-cannulated chimeric mice with a humanized liver, following oral administration of 10 mg/kg. This in vivo animal model was… read more here.
Keywords: mice humanized; chimeric mice; fenclozic acid; acid ... See more keywords
Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice
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DOI: 10.1080/00498254.2016.1247218
Abstract: Abstract 1. Pomalidomide has been shown to be potentially teratogenic in thalidomide-sensitive animal species such as rabbits. Screening for thalidomide analogs devoid of teratogenicity/toxicity – attributable to metabolites formed by cytochrome P450 enzymes – but having… read more here.
Keywords: profiles pomalidomide; human plasma; liver mice; humanized liver ... See more keywords
IL-6–GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf4490
Abstract: Liver steatosis is an increasing health issue with few therapeutic options, partly because of a paucity of experimental models. In humanized liver rodent models, abnormal lipid accumulation in transplanted human hepatocytes occurs spontaneously. Here, we… read more here.
Keywords: human hepatocytes; accumulation; humanized liver; gp130 signaling ... See more keywords
Abstract 35: Development of novel human hepatocellular carcinoma models using genetically modified human hepatocytes in FSRG humanized liver mice
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-35
Abstract: The incidence of liver cancer is growing worldwide, and it is estimated that by 2025, over 1 million individuals will be affected by liver cancer every year. Hepatocellular carcinoma (HCC) accounts for about 90% of… read more here.
Keywords: hepatocellular carcinoma; human hepatocytes; novel human; humanized liver ... See more keywords
Chimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for Porphyria-Mediated Hepatocytotoxicity
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DOI: 10.1177/01926233211027474
Abstract: Porphyrinogenic compounds are known to induce porphyria-mediated hepatocellular injury and subsequent regenerative proliferation in rodents, ultimately leading to hepatocellular tumor induction. However, an appropriate in vivo experimental model to evaluate an effect of porphyrinogenic compounds… read more here.
Keywords: porphyria mediated; mouse humanized; chimeric mouse; model ... See more keywords