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   Articles with "humanized mice" as a keyword



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Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics

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recommendations! Published in 2017 at "Cell Reports"

DOI: 10.1016/j.celrep.2017.08.003

Abstract: Summary There is growing interest in using embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) derivatives for tissue regeneration. However, an increased understanding of human immune responses to stem cell-derived allografts is necessary… read more here.

Keywords: alloimmune responses; humanized mice; stem cell; pluripotent stem ... See more keywords
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The use of humanized mice for studies of viral pathogenesis and immunity.

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recommendations! Published in 2018 at "Current opinion in virology"

DOI: 10.1016/j.coviro.2018.03.003

Abstract: Humanized mice, that is, animals engrafted with human tissues and/or expressing human genes, have been instrumental in improving our understanding of the pathogenesis and immunological processes that define some of the most challenging human-tropic viruses.… read more here.

Keywords: immune responses; pathogenesis; humanized mice; human immune ... See more keywords
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Modeling oncogenic herpesvirus infections in humanized mice.

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recommendations! Published in 2020 at "Current opinion in virology"

DOI: 10.1016/j.coviro.2020.07.005

Abstract: The creation of humanized mice generally involves the reconstitution of immunodeficient mice with human immune constituents. Different methodologies have been employed, and significant progress has been made towards the development of robustly humanized mouse models.… read more here.

Keywords: virology; oncogenic herpesvirus; herpesvirus infections; humanized mice ... See more keywords
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Viral dynamic model with cellular immune response: A case study of HIV-1 infected humanized mice

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recommendations! Published in 2019 at "Physica A: Statistical Mechanics and its Applications"

DOI: 10.1016/j.physa.2019.03.009

Abstract: Abstract In this paper, an attempt has been made to study the global dynamical behavior of a viral dynamics model incorporating both the lytic and nonlytic immune responses. The global stability of the model is… read more here.

Keywords: case study; immune response; humanized mice; model ... See more keywords
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Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-10366-y

Abstract: Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective release antiviral therapy (LASER ART) and CRISPR-Cas9 demonstrate viral clearance in latent infectious reservoirs in… read more here.

Keywords: crispr; crispr cas9; art crispr; humanized mice ... See more keywords
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CRISPR editing of CCR5 and HIV-1 facilitates viral elimination in antiretroviral drug-suppressed virus-infected humanized mice

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recommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2217887120

Abstract: Significance Long-acting antiretroviral drugs suppress viral replication in humanized mice. When administered CRISPR-mediated CCR5 and HIV-1LTR-Gag CRISPR editing the treatments resulted in the elimination of HIV-1 proviral DNA in lymphoid, bone marrow, and central nervous… read more here.

Keywords: hiv; crispr; humanized mice; crispr editing ... See more keywords
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Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after cART interruption in humanized mice.

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recommendations! Published in 2019 at "AIDS"

DOI: 10.1097/qad.0000000000002149

Abstract: OBJECTIVE The combined cART and anti-α4β7 RM-Act-1 antibody therapy allows macaques to durably control SIV rebound after withdrawal of the interventions. Here, we aimed to investigate whether vedolizumab (VDZ), a clinical-grade humanized anti-α4β7 antibody, would… read more here.

Keywords: vdz; humanized mice; cart; rebound ... See more keywords
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Evolution of SIVsm in humanized mice towards HIV‐2

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recommendations! Published in 2020 at "Journal of Medical Primatology"

DOI: 10.1111/jmp.12486

Abstract: Through the accumulation of adaptive mutations, HIV‐2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross‐species transmission event. Various adaptive mutations arose, as well… read more here.

Keywords: towards hiv; sivsm humanized; evolution sivsm; humanized mice ... See more keywords
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Evolution of SIVmac239 following serial passaging in humanized mice

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recommendations! Published in 2022 at "Journal of Medical Primatology"

DOI: 10.1111/jmp.12614

Abstract: Serial passage of SIVmac239 allows for greater understanding of the genetic changes necessary for cross‐species transmission of primate lentiviruses into humans. Using humanized mice, we show that adaptive mutations continue to accumulate in SIVmac239 during… read more here.

Keywords: humanized mice; sivmac239; following serial; evolution sivmac239 ... See more keywords

Epstein-Barr Virus Type 2 Infects T Cells and Induces B Cell Lymphomagenesis in Humanized Mice

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recommendations! Published in 2018 at "Journal of Virology"

DOI: 10.1128/jvi.00813-18

Abstract: EBV is a well-established B cell-tropic virus. However, we have recently shown that the EBV type 2 (EBV-2) strain also infects primary T cells in culture and in healthy Kenyan children. This finding suggests that… read more here.

Keywords: ebv; infection; humanized mice; model ... See more keywords
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Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice

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recommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"

DOI: 10.1136/jitc-2022-005345

Abstract: Background The immunogenic nature of metastatic colorectal cancer (CRC) with high microsatellite instability (MSI-H) underlies their responsiveness to immune checkpoint blockade (ICB). However, resistance to ICB is commonly observed, and is associated with the presence… read more here.

Keywords: immune checkpoint; peritoneal metastases; humanized mice; peritoneal ... See more keywords