Phase I–II study of OBI-888, a humanized monoclonal IgG1 antibody against the tumor-associated carbohydrate antigen Globo H, in patients with advanced solid tumors
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-024-04714-z
Abstract: OBI-888 is a humanized, monoclonal IgG1 antibody specific to the tumor-associated carbohydrate antigen Globo H. We conducted a phase I-II study of OBI-888 in patients with advanced cancer. Patients were treated with OBI-888 5, 10,… read more here.
Keywords: 888 humanized; obi 888; humanized monoclonal; tumor associated ... See more keywords
A Humanized Monoclonal Antibody Potentiates Killing of Diverse Biofilm-Forming Respiratory Tract Pathogens by Antibiotics
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01877-21
Abstract: New strategies to treat diseases in which biofilms contribute significantly to pathogenesis are needed, as biofilm-resident bacteria are highly recalcitrant to antibiotics due to physical biofilm architecture and a canonically quiescent metabolism, among many additional… read more here.
Keywords: tract pathogens; monoclonal antibody; respiratory tract; humanized monoclonal ... See more keywords
In vitro and in vivo evaluation of humanized monoclonal antibodies targeting pneumolysin
Sign Up to like & getrecommendations! Published in 2025 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00277-25
Abstract: ABSTRACT Streptococcus pneumoniae is a gram-positive bacterium that causes a variety of diseases, including otitis media, sinusitis, pneumonia, bacteremia, and meningitis. While pneumococcal conjugate vaccines have reduced disease burden globally, serotype replacement affects the effectiveness… read more here.
Keywords: monoclonal antibody; humanized monoclonal; pneumoniae; antibody ... See more keywords
Novel humanized monoclonal antibodies against ROR1 for cancer therapy
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DOI: 10.1186/s12943-024-02075-y
Abstract: Overexpression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) contributes to cancer cell proliferation, survival and migration, playing crucial roles in tumor development. ROR1 has been proposed as a potential therapeutic target for cancer treatment.… read more here.
Keywords: antibodies ror1; cancer; novel humanized; humanized monoclonal ... See more keywords
Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency
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DOI: 10.1186/s13024-017-0172-1
Abstract: BackgroundThe experience from clinical trials indicates that anti-Aβ immunotherapy could be effective in early/pre-clinical stages of AD, whereas at the late stages promoting the clearing of Aβ alone may be insufficient to halt the disease… read more here.
Keywords: tau; mab armanezumab; pathological tau; humanized monoclonal ... See more keywords
A Case of Oral Candidiasis Caused by Candida dubliniensis During Treatment of Humanized Monoclonal Antibody to Interleukin-17A.
Sign Up to like & getrecommendations! Published in 2022 at "Medical mycology journal"
DOI: 10.3314/mmj.22-00010
Abstract: We report the case of a 77-year-old woman who had been diagnosed with psoriasis vulgaris at another hospital at age 33 and treated with various therapies since then. At 61 years old, she was diagnosed… read more here.
Keywords: monoclonal antibody; antibody interleukin; treatment humanized; humanized monoclonal ... See more keywords