The humanized mouse: Emerging translational potential
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23195
Abstract: The humanized mouse (HM) has emerged as a valuable animal model in cancer research. Engrafted with components of a human immune system and subsequently implanted with tumor tissue from cell lines or in the form… read more here.
Keywords: mouse emerging; humanized mouse; emerging translational; translational potential ... See more keywords
Humanized mouse models to study human cell-mediated and humoral responses to dengue virus.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2017.07.025
Abstract: Several candidate dengue virus vaccines are in clinical trials and show promise as an effective measure to control dengue. However, it is becoming clear that additional vaccine candidates may be needed as there is concern… read more here.
Keywords: dengue virus; humanized mouse; mouse models; cell mediated ... See more keywords
A CYP2B6-humanized mouse model and its potential applications.
Sign Up to like & getrecommendations! Published in 2018 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2018.01.001
Abstract: CYP2B6 is a human microsomal cytochrome P450 enzyme with broad substrate selectivity. CYP2B6 is the only functional member of the human CYP2B gene subfamily, which differs from the situation in rodents, such as mouse, where… read more here.
Keywords: cyp2b6 humanized; drug; model; humanized mouse ... See more keywords
DNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Psychiatry"
DOI: 10.1038/s41380-024-02430-x
Abstract: Humanized mouse models can be used to explore human gene regulatory elements (REs), which frequently lie in non-coding and less conserved genomic regions. Epigenetic modifications of gene REs, also in the context of gene x… read more here.
Keywords: brain; dna methylation; humanized mouse; blood ... See more keywords
HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64945-3
Abstract: Regulatory T cells (Tregs) hold promise for treating autoimmune disease and transplant rejection, yet generation of autologous products for adoptive transfer can suffer donor variability and slow turnaround, limiting their use in urgent indications. We… read more here.
Keywords: hla class; regulatory cell; cell; model ... See more keywords
Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3–mediated therapeutics
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45839
Abstract: T cell–mediated immunotherapy is an attractive strategy for treatment in various disease areas. In this therapeutic approach, the CD3 complex is one of the key molecules to modulate T cell functions; however, in many cases,… read more here.
Keywords: cd3; cd3 humanized; entire cd3; humanized mouse ... See more keywords
Post‐transplant cyclophosphamide limits reactive donor T cells and delays the development of graft‐versus‐host disease in a humanized mouse model
Sign Up to like & getrecommendations! Published in 2021 at "Immunology"
DOI: 10.1111/imm.13374
Abstract: Graft‐versus‐host disease (GVHD) is a major complication of allogeneic haematopoietic stem cell transplantation (allo‐HSCT) that develops when donor T cells in the graft become reactive against the host. Post‐transplant cyclophosphamide (PTCy) is increasingly used in… read more here.
Keywords: ptcy; donor cells; host; mice ... See more keywords
Mechanisms of 8‐aminoquinoline induced haemolytic toxicity in a G6PDd humanized mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17362
Abstract: Primaquine (PQ) and Tafenoquine (TQ) are clinically important 8‐aminoquinolines (8‐AQ) used for radical cure treatment of P. vivax infection, known to target hepatic hypnozoites. 8‐AQs can trigger haemolytic anaemia in individuals with glucose‐6‐phosphate dehydrogenase deficiency… read more here.
Keywords: mouse model; treatment; haemolytic toxicity; humanized mouse ... See more keywords
Human and mouse bones physiologically integrate in a humanized mouse model while maintaining species-specific ultrastructure
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abb9265
Abstract: Progress has been achieved in the art of accurately mimicking human tissues and disease in a mouse. Humanized mouse models are increasingly studied to recapitulate human-like bone physiology. While human and mouse bone architectures differ… read more here.
Keywords: physiologically integrate; maintaining species; human mouse; bone ... See more keywords
Peanut allergen inhibition prevents anaphylaxis in a humanized mouse model
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.add6373
Abstract: Peanut-induced allergy is an immunoglobulin E (IgE)–mediated type I hypersensitivity reaction that manifests symptoms ranging from local edema to life-threatening anaphylaxis. Although there are treatments for symptoms in patients with allergies resulting from allergen exposure,… read more here.
Keywords: humanized mouse; chbi; peanut; allergen ... See more keywords
Predicting Optimal Antimalarial Drug Combinations from a Standardized Plasmodium falciparum Humanized Mouse Model
Sign Up to like & getrecommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01574-22
Abstract: The development of new combinations of antimalarial drugs is urgently needed to prevent the spread of parasites resistant to drugs in clinical use and contribute to the control and eradication of malaria. In this work,… read more here.
Keywords: humanized mouse; falciparum; model; drug ... See more keywords