Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast.
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DOI: 10.1093/genetics/iyab101
Abstract: Thiabendazole (TBZ) is an FDA-approved benzimidazole widely used for its antifungal and antihelminthic properties. We showed previously that TBZ is also a potent vascular disrupting agent and inhibits angiogenesis at the tissue level by dissociating… read more here.
Keywords: pesticide resistance; vascular disrupting; action; humanized yeast ... See more keywords