Metabolomic similarities between bronchoalveolar lavage fluid and plasma in humans and mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05374-1
Abstract: This observational study catalogues the overlap in metabolites between matched bronchoalveolar lavage fluid (BALF) and plasma, identifies the degree of congruence between these metabolomes in human and mouse, and determines how molecules may change in… read more here.
Keywords: plasma; bronchoalveolar lavage; balf; lavage fluid ... See more keywords
Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2204084119
Abstract: Significance Molecular components of hearing in mammalians are not completely delineated. Via a genetic approach conducted in families with sensorineural hearing loss, this study presents MINAR2 as an indispensable element of hearing in humans. Similarly,… read more here.
Keywords: hearing; hair cells; humans mice; mutations minar2 ... See more keywords
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2066581
Abstract: Abstract Despite the importance of mice as a preclinical species in drug testing, their hepatic and extrahepatic drug-metabolising characteristics are poorly understood. Here, we compared the P450-dependent drug oxidation activity in tissue microsomes and distribution… read more here.
Keywords: drug metabolising; liver intestine; hydroxylation; humans mice ... See more keywords
The use of in silico extreme pathway (ExPa) analysis to identify conserved reproductive transcriptional-regulatory networks in humans, mice, and zebrafish.
Sign Up to like & getrecommendations! Published in 2023 at "Systems biology in reproductive medicine"
DOI: 10.1080/19396368.2023.2188996
Abstract: Vertebrate sex determination and differentiation are coordinated by the activations and maintenance of reproductive transcriptional-regulatory networks (TRNs). There is considerable interest in studying the conserved design principles and functions of reproductive TRNs given that their… read more here.
Keywords: reproductive transcriptional; humans mice; mice zebrafish; differentiation ... See more keywords
Regulation of telomeric function by DNA methylation differs between humans and mice.
Sign Up to like & getrecommendations! Published in 2020 at "Human molecular genetics"
DOI: 10.1093/hmg/ddaa206
Abstract: The most distal 2 kb region in the majority of human subtelomeres contains CpG-rich promoters for TERRA, a long non-coding RNA. When the function of the de novo DNA methyltransferase DNMT3B is disrupted, as in ICF1… read more here.
Keywords: methylation; dna; function; dna methylation ... See more keywords
ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/7281986
Abstract: Obesity is one of the most prevalent metabolic diseases in the Western world and correlates directly with insulin resistance, which may ultimately culminate in type 2 diabetes (T2D). We sought to ascertain whether the human… read more here.
Keywords: diet induced; metabolic syndrome; insulin resistance; obesity ... See more keywords
Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010114
Abstract: The highly evolutionarily conserved transport protein particle (TRAPP) complexes (TRAPP II and III) perform fundamental roles in subcellular trafficking pathways. Here we identified biallelic variants in TRAPPC10, a component of the TRAPP II complex, in… read more here.
Keywords: humans mice; trappc10; biallelic variants; variants trappc10 ... See more keywords
Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911372
Abstract: Platelets are crucial for hemostasis and arterial thrombosis, which may lead to severe cardiovascular diseases (CVDs). Thus, therapeutic agents must be developed to prevent pathological platelet activation. Glabridin, a major bioalkaloid extracted from licorice root,… read more here.
Keywords: platelet activation; mice glabridin; humans mice; effectively inhibits ... See more keywords