Comparative profiling of serum, urine, and feces bile acids in humans, rats, and mice
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-06321-3
Abstract: Bile acids (BAs) play important pathophysiological roles in both humans and mammalian animals. Laboratory rats and mice are widely used animal models for assessing pharmacological effects and their underlying molecular mechanisms. However, substantial physiological differences… read more here.
Keywords: bile acids; murine rodents; urine feces; serum urine ... See more keywords
Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2131484
Abstract: Abstract Acyl glucuronides (AGs) are known as one of the causes of idiosyncratic drug toxicity (IDT). Although AGs can be enzymatically hydrolysed by β-glucuronidase and esterase, much information on their characteristics and species differences is… read more here.
Keywords: species differences; humans rats; acyl; hydrolysis ... See more keywords
Surface mapping of gastric motor functions using MRI: a comparative study between humans and rats
Sign Up to like & getrecommendations! Published in 2024 at "American Journal of Physiology - Gastrointestinal and Liver Physiology"
DOI: 10.1152/ajpgi.00045.2024
Abstract: BACKGROUND The stomach's ability to store, mix, propel, and empty its content requires highly coordinated motor functions. However, current diagnostic tools cannot simultaneously assess these motor processes. This study aimed to use magnetic resonance imaging… read more here.
Keywords: physiology; gastric motor; motor functions; humans rats ... See more keywords