Imaging Mutant Huntingtin Aggregates: Development of a Potential PET ligand.
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DOI: 10.1021/acs.jmedchem.0c00955
Abstract: Mutant huntingtin (mHTT) protein carrying the elongated N-terminal polyglutamine (polyQ) tract misfolds and forms protein aggregates characteristic of HD pathology. A high-affinity ligand specific for mHTT aggregates could serve as a positron emission tomography (PET)… read more here.
Keywords: pet; huntingtin aggregates; development; mutant huntingtin ... See more keywords