Small-Molecule Disruptors of Mutant Huntingtin-Calmodulin Protein-Protein Interaction Attenuate Deleterious Effects of Mutant Huntingtin.
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DOI: 10.1021/acschemneuro.2c00305
Abstract: Huntington's disease is a progressive and lethal neurodegenerative disease caused by an increased CAG repeat mutation in exon 1 of the huntingtin gene (mutant huntingtin). Current drug treatments provide only limited symptomatic relief without impacting… read more here.
Keywords: huntington disease; huntingtin; mutant huntingtin; huntingtin calmodulin ... See more keywords