Forms and Phases in Huntingtin Protein Aggregation.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.05.004
Abstract: Using a combination of fluorescence microscopy and electron tomography, Peskett et al. (2018), in this issue of Molecular Cell, explore the nucleation of amyloid-like filaments from liquid-like condensates of huntingtin protein exon1 with disease-related polyQ extensions. read more here.
Keywords: phases huntingtin; microscopy; huntingtin protein; forms phases ... See more keywords
The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain.
Sign Up to like & getrecommendations! Published in 2020 at "Structure"
DOI: 10.1016/j.str.2020.06.008
Abstract: The polyQ expansion in huntingtin protein (HTT) is the prime cause of Huntington's disease (HD). The recent cryoelectron microscopy (cryo-EM) structure of HTT-HAP40 complex provided the structural information on its HEAT-repeat domains. Here, we present… read more here.
Keywords: htt; expansion; huntingtin protein; terminal ... See more keywords
Lowering mutant huntingtin protein
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-019-00207-4
Abstract: Human genetic studies have established the orphan G proteincoupled receptor gene, GPR146, as a regulator of plasma cholesterol levels. In line with these findings, Yu et al. report that depletion of GPR146 in mice substantially… read more here.
Keywords: huntingtin protein; mutant huntingtin; lowering mutant;
Prion-like properties of the mutant huntingtin protein in living organisms: the evidence and the relevance
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Psychiatry"
DOI: 10.1038/s41380-021-01350-4
Abstract: If theories postulating that pathological proteins associated with neurodegenerative disorders behave similarly to prions were initially viewed with reluctance, it is now well-accepted that this occurs in several disease contexts. Notably, it has been reported… read more here.
Keywords: properties mutant; huntingtin protein; prion like; prion ... See more keywords
Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Huntington's Disease"
DOI: 10.3233/jhd-220538
Abstract: Background: Huntington’s disease (HD) is a genetic neurodegenerative disease caused by trinucleotide repeat (CAG) expansions in the human HTT gene encoding the huntingtin protein (Htt) with an expanded polyglutamine tract. Objective: HD models from yeast… read more here.
Keywords: huntingtin protein; htt; huntington disease; disease ... See more keywords
Comparative molecular dynamics simulations of pathogenic and non-pathogenic huntingtin protein monomers and dimers
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1143353
Abstract: Polyglutamine expansion at the N-terminus of the huntingtin protein exon 1 (Htt-ex1) is closely associated with a number of neurodegenerative diseases, which result from the aggregation of the increased polyQ repeat. However, the underlying structures… read more here.
Keywords: dynamics simulations; huntingtin protein; molecular dynamics; non pathogenic ... See more keywords