Validation of a prognostic index for Huntington's disease
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.26838
Abstract: Characterizing progression in Huntington's disease is important for study the natural course and selecting appropriate participants for clinical trials. read more here.
Keywords: index huntington; validation prognostic; huntington disease; huntington ... See more keywords
Design optimization for clinical trials in early‐stage manifest Huntington's disease
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DOI: 10.1002/mds.27122
Abstract: The purpose of this study was to inform the design of randomized clinical trials in early‐stage manifest Huntington's disease through analysis of longitudinal data from TRACK‐Huntington's Disease (TRACK‐HD), a multicenter observational study. read more here.
Keywords: trials early; huntington disease; huntington; clinical trials ... See more keywords
Neurofilament Light Protein as a Potential Blood Biomarker for Huntington's Disease in Children
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.29027
Abstract: Juvenile‐onset Huntington's disease (JOHD) is a rare and particularly devastating form of Huntington's disease (HD) for which clinical diagnosis is challenging and robust outcome measures are lacking. Neurofilament light protein (NfL) in plasma has emerged… read more here.
Keywords: huntington; biomarker; huntington disease; neurofilament light ... See more keywords
George Huntington (1850–1916)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurology"
DOI: 10.1007/s00415-018-8860-5
Abstract: To the memory of Magdalena P. and all my patients with Huntington’s disease that I was unable to help as I wished. The nineteenth century was a time when specializations evolved from general medicine. General… read more here.
Keywords: medicine; huntington; george huntington; disease ... See more keywords
Recent developments in the management of Huntington's disease.
Sign Up to like & getrecommendations! Published in 2022 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2022.105642
Abstract: Huntington's disease (HD) is a rare, incurable, inheritedneurodegenerative disorder manifested by chorea, hyperkinetic, and hypokinetic movements. The FDA has approved only two drugs, viz. tetrabenazine, and deutetrabenazine, to manage the chorea associated with HD. However,… read more here.
Keywords: huntington disease; recent developments; management huntington; huntington ... See more keywords
Evaluation of 4-oxo-quinoline-based CB2 PET radioligands in R6/2 chorea huntington mouse model and human ALS spinal cord tissue.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.12.097
Abstract: The cannabinoid receptor 2 (CB2) has been implicated in a series of neurodegenerative disorders and has emerged as an interesting biological target for therapeutic as well as diagnostic purposes. In the present work, we describe… read more here.
Keywords: huntington; als spinal; cb2; human als ... See more keywords
5,6,7 trihydroxy flavone armoured neurodegeneration caused by Quinolinic acid induced huntington’s like disease in rat striatum - reinstating the level of brain neurotrophins with special reference to cognitive-socio behaviour, biochemical and histopathological aspects
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience research"
DOI: 10.1016/j.neures.2021.08.003
Abstract: Huntington Disease (HD), a predominant Neurodegenerative Disorder which might be induced by endogenous neurotoxin called Quinolinic Acid (QA), an N-methyl-D aspartate receptor (NMDAR) agonist, the bilaterally intrastriatal administration (200 nm/2 µl of saline) offers rise to the… read more here.
Keywords: huntington; striatum; disease; trihydroxy flavone ... See more keywords
Transcranial direct current stimulation can enhance working memory in Huntington's disease
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2017.04.002
Abstract: ABSTRACT Transcranial direct current stimulation (tDCS) combined with a cognitive task can enhance targeted aspects of cognitive functioning in clinical populations. The movement disorder Huntington's disease (HD) is associated with progressive cognitive impairment. Deficits in… read more here.
Keywords: tdcs; stimulation; huntington; current stimulation ... See more keywords
[A qualitative study on the impact on the grandparent-grandchildren relationship in Huntington's disease].
Sign Up to like & getrecommendations! Published in 2021 at "Semergen"
DOI: 10.1016/j.semerg.2021.01.008
Abstract: The objective of the research is twofold: (1) To understand the emotional process of coping with being at risk or being symptomatic of Huntington's disease (HD), and its effect on the relationship between grandparents and… read more here.
Keywords: impact grandparent; huntington disease; huntington; study ... See more keywords
Erythropoietin and Bacillus Calmette-Guérin Vaccination Mitigate 3-Nitropropionic Acid-Induced Huntington-like Disease in Rats by Modulating the PI3K/Akt/mTOR/P70S6K Pathway and Enhancing the Autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00523
Abstract: Oxidative stress and mitochondrial dysfunction are among the mechanisms expected to explain the pathogenesis of Huntington's disease. Erythropoietin (EPO) and the Bacillus Calmette-Guérin (BCG) vaccine have neuroprotective effects against neurodegenerative diseases; however, the full mechanisms… read more here.
Keywords: pi3k akt; disease; like disease; akt mtor ... See more keywords
Neuroinflammation in Huntington's Disease: New Insights with 11C-PBR28 PET/MRI.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00072
Abstract: Huntington's disease is a devastating neurodegenerative genetic disorder that causes progressive motor dysfunction, emotional disturbances, and cognitive impairment. Unfortunately, there is no treatment to cure or slow the progression of the disease. Neuroinflammation is one… read more here.
Keywords: pet; huntington disease; huntington; neuroinflammation ... See more keywords