An image‐based model of brain volume biomarker changes in Huntington's disease
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.558
Abstract: Determining the sequence in which Huntington's disease biomarkers become abnormal can provide important insights into the disease progression and a quantitative tool for patient stratification. Here, we construct and present a uniquely fine‐grained model of… read more here.
Keywords: image based; huntington disease; disease; model brain ... See more keywords
Inhibition of polyglutamine aggregation by SIMILAR huntingtin N‐terminal sequences: Prospective molecules for preclinical evaluation in Huntington's disease
Sign Up to like & getrecommendations! Published in 2017 at "Peptide Science"
DOI: 10.1002/bip.23021
Abstract: The mutant huntingtin protein (mHtt) fragments with expanded polyglutamine sequence forms microscopically visible aggregates in neurons, a hallmark of Huntington's disease (HD). The aggregation process and aggregates are possible targets of therapeutic intervention in HD.… read more here.
Keywords: huntingtin; aggregation; huntington disease; preclinical evaluation ... See more keywords
Altered third‐party punishment in Huntington's disease: A study using neuroeconomic games
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1908
Abstract: Huntington's disease (HD) is a heritable degenerative brain disease caused by a mutation in the huntingtin gene with excessive repeats of the base triplet cytosine–adenine–guanine (CAG), which codes for the aminoacid glutamine. HD is associated… read more here.
Keywords: huntington disease; altered third; study; disease ... See more keywords
No optical coherence tomography changes in premanifest Huntington's disease mutation carriers far from disease onset
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2592
Abstract: Spectral‐domain optical coherence tomography (OCT) may detect retinal changes as a biomarker in neurodegenerative diseases like manifest Huntington's disease (HD). We investigate macular retinal layer thicknesses in a premanifest HD (pre‐HD) cohort and healthy controls… read more here.
Keywords: coherence tomography; optical coherence; huntington disease;
Mental health symptoms among those affected by Huntington's disease: A cross‐sectional study
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2954
Abstract: Although cognitive and motor symptoms of Huntington's disease (HD) are associated with disease progression, the underlying causes of psychological symptoms are not as clearly understood. Recent evidence suggests that some mental health difficulties experienced by… read more here.
Keywords: huntington disease; disease; symptoms among; health symptoms ... See more keywords
Network spread determines severity of degeneration and disconnection in Huntington's disease
Sign Up to like & getrecommendations! Published in 2019 at "Human Brain Mapping"
DOI: 10.1002/hbm.24695
Abstract: Trans‐neuronal propagation of mutant huntingtin protein contributes to the organised spread of cortico‐striatal degeneration and disconnection in Huntington's disease (HD). We investigated whether the network diffusion model, which models transneuronal spread as diffusion of pathological… read more here.
Keywords: degeneration disconnection; huntington disease; disconnection; brain ... See more keywords
Aberrant brain network connectivity in presymptomatic and manifest Huntington's disease: A systematic review
Sign Up to like & getrecommendations! Published in 2019 at "Human Brain Mapping"
DOI: 10.1002/hbm.24790
Abstract: Resting‐state functional magnetic resonance imaging (rs‐fMRI) has the potential to shed light on the pathophysiological mechanisms of Huntington's disease (HD), paving the way to new therapeutic interventions. A systematic literature review was conducted in three… read more here.
Keywords: network; huntington disease; connectivity; connectivity presymptomatic ... See more keywords
Comprehensive shape analysis of the cortex in Huntington's disease
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.26125
Abstract: The striatum has traditionally been the focus of Huntington's disease research due to the primary insult to this region and its central role in motor symptoms. Beyond the striatum, evidence of cortical alterations caused by… read more here.
Keywords: huntington disease; disease; local gyrification; cortical thickness ... See more keywords
Dilemmas when talking about Huntington's disease: A qualitative study of offspring and caregiver experiences in Norway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Genetic Counseling"
DOI: 10.1002/jgc4.1610
Abstract: Research provides a compelling list of reasons why offspring should be included in honest conversations about disease when the disease affects their caregivers. Despite this, we lack in‐depth knowledge about how families affected by the… read more here.
Keywords: huntington disease; disease; dilemmas talking; families affected ... See more keywords
Mechanisms underlying the enhancement of γ‐aminobutyric acid responses in the external globus pallidus of R6/2 Huntington’s disease model mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24710
Abstract: In Huntington's disease (HD), the output of striatal indirect pathway medium‐sized spiny neurons (MSNs) is altered in its target region, the external globus pallidus (GPe). In a previous study we demonstrated that selective optogenetic stimulation… read more here.
Keywords: globus pallidus; external globus; huntington disease; mice ... See more keywords
Hippocampal and striatal volumes correlate with spatial memory impairment in Huntington's disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuroscience research"
DOI: 10.1002/jnr.24966
Abstract: Spatial memory impairments are observed in people with Huntington's disease (HD), however, the domain of spatial memory has received little focus when characterizing the cognitive phenotype of HD. Spatial memory is traditionally thought to be… read more here.
Keywords: striatal volumes; spatial memory; huntington disease; hippocampal striatal ... See more keywords