Simultaneous separation and determination of three huperzine alkaloids in Huperzia serrata and its preparations by cyclodextrin-modified mixed micellar electrokinetic capillary chromatography.
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DOI: 10.1016/j.ab.2021.114207
Abstract: In this study, a simple and sensitive cyclodextrin-modified mixed micellar electrokinetic capillary chromatography (CD-MEKC) method has been developed for the simultaneous separation and determination of Huperzine A (HupA), Huperzine B (HupB) and Huperzine C (HupC)… read more here.
Keywords: modified mixed; determination; separation determination; separation ... See more keywords
Development of a Capillary Electrophoretic Method for the Determination of Huperzine A Concentration in Vietnamese Huperzia serrata
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DOI: 10.1177/1934578x211033225
Abstract: Huperzine A, isolated from Huperzia serrata, is a potent, specific, and reversible inhibitor of acetylcholinesterase with high efficiency and low toxicity. To evaluate the presence of huperzine A in Vietnamese H serrata, a reliable capillary… read more here.
Keywords: huperzia serrata; method; huperzine; development capillary ... See more keywords
Development and Evaluation of Huperzine A-Loaded Microneedles for Transdermal Delivery and Pretreatment of GD Poisoning
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DOI: 10.1208/s12249-025-03149-w
Abstract: Huperzine A (Hup A), a reversible acetylcholinesterase inhibitor, shows protective potential against neurotoxic poisoning. Current formulations (oral tablets/capsules and injectables) face limitations: oral administration suffers from first-pass metabolism and fluctuating plasma concentrations due to frequent… read more here.
Keywords: huperzine; administration; hup; study ... See more keywords
Down-modulation of endoplasmic reticulum stressinitiated apoptosis by huperzine A in isoproterenolprovoked myocardial infarction rat model: Role of Nrf2/HO- 1 signaling axis
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DOI: 10.4314/tjpr.v19i8.17
Abstract: Purpose: To investigate the myocardial protective effect of huperzine A (HPA), a sesquiterpene alkaloid, in a rat model of isoproterenol (ISP)- provoked MI and ER stress.Methods: Three groups of rats were used: control, ISP and… read more here.
Keywords: endoplasmic reticulum; rat model; huperzine; apoptosis ... See more keywords