Structural and dynamical determinants of a β-sheet-enriched intermediate involved in amyloid fibrillar assembly of human prion protein
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DOI: 10.1039/d2sc00345g
Abstract: The conformational conversion of the cellular prion protein (PrPC) into a misfolded, aggregated and infectious scrapie isoform is associated with prion disease pathology and neurodegeneration. Despite the significant number of experimental and theoretical studies the… read more here.
Keywords: prion; structural dynamical; prion protein; huprp 231 ... See more keywords