LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR‐184 in chronic myelogenous leukaemia cells
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13480
Abstract: Chemotherapy is a major anticancer therapeutic modality, however, multidrug resistance (MDR) is frequently observed and hinders treatment efficacy. Here, we investigated the role and potential mechanism of the long noncoding RNA (lncRNA) FENDRR in adriamycin… read more here.
Keywords: hur; lncrna fendrr; resistance; mir 184 ... See more keywords
HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23137
Abstract: In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), chronic activation of microglia contributes to disease progression. Activated microglia produce cytokines, chemokines, and other factors that normally serve to clear infection or damaged tissue either… read more here.
Keywords: phenotype; hur; neurodegenerative diseases; amyotrophic lateral ... See more keywords
Deletion of the RNA regulator HuR in tumor‐associated microglia and macrophages stimulates anti‐tumor immunity and attenuates glioma growth
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23696
Abstract: Glioblastoma is a malignant brain tumor that portends a poor prognosis. Its resilience, in part, is related to a remarkable capacity for manipulating the microenvironment to promote its growth and survival. Microglia/macrophages are prime targets,… read more here.
Keywords: tumor associated; hur; rna regulator; microglia macrophages ... See more keywords
CircZNF418 Prevents Intervertebral Disc Degeneration by Targeting the HuR/SIRT6 Axis to Protect Against Oxidative Stress‐Induced Ferroptosis and Senescence
Sign Up to like & getrecommendations! Published in 2025 at "IUBMB Life"
DOI: 10.1002/iub.70049
Abstract: Intervertebral disc degeneration (IVDD) is a common degenerative disorder affecting the spine. Ferroptosis and cellular senescence are key pathological features driving IVDD progression, but the mechanisms involved in their regulation remain incompletely understood. While circular… read more here.
Keywords: senescence; circznf418; oxidative stress; ferroptosis ... See more keywords
Peptide-Based Nanoparticles Suppress Hepatic Inflammation via Blockage of Human Antigen R.
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202406963
Abstract: Human antigen R (HuR), which is a mRNA-binding protein that stabilizes and regulates mRNA translation, is found to have increased expression in inflammation, cancer and other diseases, making HuR to be a promising drug target.… read more here.
Keywords: human antigen; hur; hepatic inflammation; peptide based ... See more keywords
Ursolic acid reduces Adriamycin resistance of human ovarian cancer cells through promoting the HuR translocation from cytoplasm to nucleus
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Toxicology"
DOI: 10.1002/tox.23032
Abstract: Ursolic acid (UA) has been shown to suppress various tumor progression, however, its roles in Adriamycin resistance of human ovarian cancer (OC) cells are still unclear. This work aims to investigate the effects of UA… read more here.
Keywords: skov3; ursolic acid; hur; resistance ... See more keywords
MiR-4458/human antigen R (HuR) modulates PBX3 mRNA stability in melanoma tumorigenesis
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-020-02051-8
Abstract: Melanoma, a malignancy of the melanocyte, is characterized as the most fatal skin cancer with an increasing incidence. Of note, in spite of great attempts made for better treatment, the therapeutic outcome is barely satisfactory.… read more here.
Keywords: melanoma; pbx3 mrna; human antigen; hur ... See more keywords
High cytoplasmic HuR expression is associated with advanced pT stage, high grade and increased microvessel density in urothelial bladder carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2017.12.002
Abstract: PURPOSE HuR (human antigen R) protein is a RNA binding protein that stabilizes the mRNA and controls the translation of genes involved in cell proliferation, differentiation, and carcinogenesis. Overexpression of HuR was reported in a… read more here.
Keywords: hur; mvd; hur expression; expression ... See more keywords
Involvement of HuR in the serum starvation induced autophagy through regulation of Beclin1 in breast cancer cell-line, MCF-7.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.05.008
Abstract: Starvation is a cellular stress that induces autophagy, a conserved cellular self-digestion mechanism that allows cells to degrade and recycle damaged proteins and organelles. The present study illustrated that during serum deprivation, Beclin1, a crucial… read more here.
Keywords: beclin1; cell line; starvation; hur ... See more keywords
RNA-Binding Protein HuR Regulates Rac1 Nucleocytoplasmic Shuttling Through Nucleophosmin in the Intestinal Epithelium
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2019.06.002
Abstract: Background & Aims The mammalian intestinal epithelium is a rapidly self-renewing tissue in the body, and its homeostasis is tightly regulated via well-controlled mechanisms. The RNA-binding protein HuR is essential for maintaining gut epithelial integrity,… read more here.
Keywords: intestinal epithelium; hur; rna binding; binding protein ... See more keywords
Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.12.006
Abstract: The 3' untranslated region (UTR) of mRNAs is the primary regulatory region that mediates post-transcriptional control by microRNAs and RNA-binding proteins in the cytoplasm. Aside from individual sequence-specific binding and regulation, examples of interaction between… read more here.
Keywords: wide identification; identification validation; hur; validation interactions ... See more keywords