Binding specificity of HuScFv to cholangiocarcinoma cells; New avenues for diagnosis and treatment.
Sign Up to like & getrecommendations! Published in 2024 at "Asian Pacific journal of allergy and immunology"
DOI: 10.12932/ap-210624-1877
Abstract: BACKGROUND Cholangiocarcinoma (CCA) is a very aggressive cancer of the bile ducts. Recent advances in immunotherapy, particularly with human single-chain variable fragments (HuScFv), have shown promise in the treatment of solid tumors by targeting cancer… read more here.
Keywords: cca; treatment; specificity; cholangiocarcinoma ... See more keywords
A novel anti-membrane CD30 single-chain variable fragment discovered from the human phage library: A potential targeted immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0284708
Abstract: Hodgkin’s lymphoma and anaplastic large cell lymphoma, especially relapsed or refractory diseases, could recently be cured by CD30-targeted immunotherapy. However, the CD30 antigen releases the soluble ectodomain of CD30, which might obscure the targeted therapy.… read more here.
Keywords: targeted immunotherapy; cd30; huscfv; single chain ... See more keywords
Cytoplasmic Chaperones Enhance Soluble Expression of Anti-EGFR huscFv in Escherichia coli
Sign Up to like & getrecommendations! Published in 2020 at "Iranian Journal of Biotechnology"
DOI: 10.30498/ijb.2020.138200.2314
Abstract: Background: Overexpression of EGFR is associated with carcinogenesis in more than 70% of head and neck cancers. Anti-EGFR monoclonal antibodies bind to the extracellular domain of EGFR and block the EGFR downstream signaling pathway, which… read more here.
Keywords: expression; huscfv; escherichia coli; egfr ... See more keywords