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   Articles with "huvecs" as a keyword



Carbofuran cytotoxicity, DNA damage, oxidative stress, and cell death in human umbilical vein endothelial cells: Evidence of vascular toxicity

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recommendations! Published in 2021 at "Journal of Applied Toxicology"

DOI: 10.1002/jat.4150

Abstract: Carbofuran is a broad‐spectrum carbamate insecticide, which principally inhibits the acetylcholinesterase (AChE) enzyme in the nervous system. Nonetheless, their selective action is not restricted to a single species and expanded to humans. No studies are… read more here.

Keywords: carbofuran; human umbilical; huvecs; endothelial cells ... See more keywords

miR‐125a‐3p aggravates ox‐LDL‐induced HUVEC injury through BAMBI

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recommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.23198

Abstract: Atherosclerosis (AS) is a chronic inflammatory disease characterized by the formation of atherosclerotic plaque in the intima of arteries. Among the known regulators of atherosclerosis, microRNAs (miRNAs) have been reported to play critical roles in… read more here.

Keywords: huvecs; mir 125a; bambi; 125a aggravates ... See more keywords

Regulation of endothelial cell senescence via the miR-217/FOXO3 axis

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recommendations! Published in 2025 at "Biogerontology"

DOI: 10.1007/s10522-025-10290-3

Abstract: The accumulation of senescent endothelial cells within the endothelium leads to vascular dysfunction. Independent studies have linked miR-217, a senescence-associated microRNA and FOXO3, a longevity factor, to cellular senescence in different study models. However, their… read more here.

Keywords: senescence; foxo3 axis; mir 217; huvecs ... See more keywords

Evodiamine attenuates TGF-β1-induced fibroblast activation and endothelial to mesenchymal transition

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recommendations! Published in 2017 at "Molecular and Cellular Biochemistry"

DOI: 10.1007/s11010-017-2956-6

Abstract: The aim of this study is to investigate the effect of evodiamine on fibroblast activation in cardiac fibroblasts and endothelial to mesenchymal transition (EndMT) in human umbilical vein endothelial cells (HUVECs). Neonatal rat cardiac fibroblasts… read more here.

Keywords: endothelial mesenchymal; huvecs; cardiac fibroblasts; activation ... See more keywords

Differential sex-specific effects of oxygen toxicity in human umbilical vein endothelial cells.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.03.058

Abstract: Despite the well-established sex-specific differences in the incidence of bronchopulmonary dysplasia (BPD), the molecular mechanism(s) behind these are not completely understood. Pulmonary angiogenesis is critical for alveolarization and arrest in vascular development adversely affects lung… read more here.

Keywords: vein endothelial; sex specific; sex; huvecs ... See more keywords

Activation of Keap1-Nrf2 signaling by 4-octyl itaconate protects human umbilical vein endothelial cells from high glucose.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.12.032

Abstract: High glucose (HG) induces oxidative injury to cultured human umbilical vein endothelial cells (HUVECs). Recent studies have discovered 4-octyl itaconate (OI) as a novel and cell permeable Nrf2 (nuclear-factor-E2-related factor 2) activator. Its potential activity… read more here.

Keywords: keap1 nrf2; vein endothelial; human umbilical; high glucose ... See more keywords

Tetramethylpyrazine alleviates LPS-induced inflammatory injury in HUVECs by inhibiting Rho/ROCK pathway.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.04.135

Abstract: Endothelial dysfunction plays an important role in the pathogenesis of acute lung injury (ALI). Tetramethylpyrazine (TMP) has been reported to attenuate harmful changes in ALI rats. However, the effects of TMP on endothelial cell injury… read more here.

Keywords: inflammatory injury; lps group; group; huvecs ... See more keywords

Atmospheric PM2.5 blocking up autophagic flux in HUVECs via inhibiting Sntaxin-17 and LAMP2.

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recommendations! Published in 2020 at "Ecotoxicology and environmental safety"

DOI: 10.1016/j.ecoenv.2020.111450

Abstract: Despite of growing evidence linking PM2.5 exposure to autophagic activity in various human cells, the functional significance of PM2.5 exposure affecting autophagy in the pathogenesis of human cardiovascular disease and the underlying molecular mechanisms remain… read more here.

Keywords: pm2; sntaxin lamp2; flux huvecs; autophagic flux ... See more keywords

L-Threoascorbic acid treatment promotes S. aureus-infected primary human endothelial cells survival and function, as well as intracellular bacterial killing, and immunomodulates the release of IL-1β and soluble ICAM-1.

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recommendations! Published in 2021 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2021.107476

Abstract: BACKGROUND Vitamin C (ascorbic acid, AscH2) has been shown to enhance immunity. Here, we studied its immunomodulatory effect on human endothelial cells (ECs) during S. aureus infection. MATERIALS AND METHODS The ex vivo effects of… read more here.

Keywords: asch2 treatment; treatment; huvecs; endothelial cells ... See more keywords

Decrease in the inflammatory cytokines of LPS-stimulated PBMCs of patients with atherosclerosis by a TLR-4 antagonist in the co-culture with HUVECs.

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recommendations! Published in 2021 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2021.108295

Abstract: Toll-like receptors (TLRs) are among the players of inflammation during atherosclerosis. We assessed the effects of Eritoran, a TLR-4 antagonist, on lipopolysaccharide (LPS)-induced cytokines production by Peripheral Blood Mononuclear Cells (PBMCs) of patients with high-stenosis… read more here.

Keywords: 005 007; pbmcs patients; 005 005; 007 005 ... See more keywords

NR4A3 induces endothelial dysfunction through up-regulation of endothelial 1 expression in adipose tissue-derived stromal cells.

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recommendations! Published in 2020 at "Life sciences"

DOI: 10.1016/j.lfs.2020.118727

Abstract: Hypertension is one of the most prevalent diseases worldwide. Increased synthesis of the vasoconstrictor peptide endothelin 1 (encoded by EDN1) might be responsible for high blood pressure. The present study further confirmed the abnormal EDN1… read more here.

Keywords: derived stromal; stromal cells; expression; huvecs ... See more keywords