LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "huwe1" as a keyword



HUWE1‐Mediated Degradation of MUTYH Facilitates DNA Damage and Mitochondrial Dysfunction to Promote Acute Kidney Injury

Sign Up to like & get
recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202412250

Abstract: The role of MUTYH, a DNA repair glycosylase in the pathogenesis of acute kidney injury (AKI) is unclear. In this study, it is found that MUTYH protein levels are significantly decreased in the kidneys of… read more here.

Keywords: dna damage; huwe1; dysfunction; injury ... See more keywords

HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis.

Sign Up to like & get
recommendations! Published in 2025 at "Advanced science"

DOI: 10.1002/advs.202516719

Abstract: Iron is critical to optimal athletic performance because of its role in energy metabolism, oxygen transport, and acid‐base balance. However, the precise mechanism how skeletal muscle maintains iron homeostasis during exercise remains enigmatic. Here, it… read more here.

Keywords: skeletal muscle; huwe1; homeostasis; muscle ... See more keywords

CRL4BRBBP7 targets HUWE1 for ubiquitination and proteasomal degradation.

Sign Up to like & get
recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.05.008

Abstract: The E3 ubiquitin ligase HUWE1/Mule/ARF-BP1 plays an important role in diverse biological processes including DNA damage repair and apoptosis. Our previous study has shown that in response to DNA damage HUWE1 was downregulated in CUL4B-mediated… read more here.

Keywords: dna damage; degradation; huwe1; proteasomal degradation ... See more keywords

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.

Sign Up to like & get
recommendations! Published in 2018 at "Molecular cell"

DOI: 10.1016/j.molcel.2018.09.017

Abstract: mTORC1, the major homeostatic sensor and responder, regulates cell catabolism mainly by targeting autophagy. Here, we show that mTORC1 directly controls autophagosome formation via phosphorylation of WIPI2, a critical protein in isolation membrane growth and… read more here.

Keywords: degradation; huwe1; regulated huwe1; mtorc1 ... See more keywords

HUWE1 loss promotes stemness and drug resistance in CRC with dysregulated β-catenin destruction complex

Sign Up to like & get
recommendations! Published in 2025 at "Cell Death Discovery"

DOI: 10.1038/s41420-025-02731-2

Abstract: Cancer stem cells (CSCs) are a key driver of tumor initiation, progression, and drug resistance in colorectal cancer (CRC). The Wnt/β-catenin signaling pathway, which is hyperactivated in nearly all CRC cases, plays a crucial role… read more here.

Keywords: huwe1; catenin; destruction complex; drug resistance ... See more keywords

The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance

Sign Up to like & get
recommendations! Published in 2025 at "PLOS Genetics"

DOI: 10.1371/journal.pgen.1011677

Abstract: WNT/β-catenin signaling is mediated by the transcriptional coactivator β-catenin (CTNNB1). CTNNB1 abundance is regulated by phosphorylation and proteasomal degradation, promoted by a destruction complex composed of the scaffold proteins APC and AXIN1 or AXIN2, and… read more here.

Keywords: abundance; huwe1; degradation; destruction complex ... See more keywords

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

Sign Up to like & get
recommendations! Published in 2017 at "EMBO Molecular Medicine"

DOI: 10.15252/emmm.201606684

Abstract: Cancer genome sequencing projects have identified hundreds of genetic alterations, often at low frequencies, raising questions as to their functional relevance. One exemplar gene is HUWE1, which has been found to be mutated in numerous… read more here.

Keywords: dna damage; huwe1; suppressor gene; tumour suppressor ... See more keywords

Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life

Sign Up to like & get
recommendations! Published in 2024 at "Life Science Alliance"

DOI: 10.26508/lsa.202302370

Abstract: The recently discovered HAPSTR1 protein facilitates a nuclear quality control pathway essential for mammalian life. The recently discovered HAPSTR1 protein broadly oversees cellular stress responses. This function requires HUWE1, a ubiquitin ligase that paradoxically marks… read more here.

Keywords: huwe1; essential mammalian; life; hapstr1 ... See more keywords

The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases

Sign Up to like & get
recommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2022.905906

Abstract: E3 ubiquitin ligases determine the substrate specificity and catalyze the ubiquitination of lysine residues. HUWE1 is a catalytic HECT domain-containing giant E3 ligase that contains a substrate-binding ring structure, and mediates the ubiquitination of more… read more here.

Keywords: giant ligase; linked tumorigenesis; ligase huwe1; huwe1 ... See more keywords

Associations between Huwe1 and autophagy in rat cerebral neuron oxygen-glucose deprivation and reperfusion injury

Sign Up to like & get
recommendations! Published in 2020 at "Molecular Medicine Reports"

DOI: 10.3892/mmr.2020.11611

Abstract: Autophagy and the ubiquitin proteasome system (UPS) are two major protein degradation pathways involved in brain ischemia. Autophagy can compensate for UPS impairment-induced cellular dysfunction. HECT, UBA and WWE domain containing E3 ubiquitin protein ligase… read more here.

Keywords: huwe1; huwe1 autophagy; glucose deprivation; oxygen glucose ... See more keywords

Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer

Sign Up to like & get
recommendations! Published in 2019 at "Oncology Letters"

DOI: 10.3892/ol.2019.10579

Abstract: E3 ubiquitin-protein ligase (HUWE1) has previously been identified as a HECT domain-containing ubiquitin ligase (E3) that is involved in several signaling pathways, transcriptional regulation, neural differentiation, DNA damage responses and apoptosis. However, the function of… read more here.

Keywords: hect domain; huwe1; ligase huwe1; expression ... See more keywords