The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases
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DOI: 10.3389/fcimb.2022.905906
Abstract: E3 ubiquitin ligases determine the substrate specificity and catalyze the ubiquitination of lysine residues. HUWE1 is a catalytic HECT domain-containing giant E3 ligase that contains a substrate-binding ring structure, and mediates the ubiquitination of more… read more here.
Keywords: giant ligase; linked tumorigenesis; ligase huwe1; huwe1 ... See more keywords