Differential expression of the long and truncated Hv1 isoforms in breast‐cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29719
Abstract: Metabolic reprogramming of cancer cells results in a high production of acidic substances that must be extruded to maintain tumor‐cell viability. The voltage‐gated proton channel (Hv1) mediates highly selective effluxes of hydronium‐ion (H+) that prevent… read more here.
Keywords: breast cancer; cancer cells; cancer; hv1 ... See more keywords
The voltage-gated proton channel Hv1 plays a detrimental role in contusion spinal cord injury via extracellular acidosis-mediated neuroinflammation
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.10.005
Abstract: Tissue acidosis is an important secondary injury process in the pathophysiology of traumatic spinal cord injury (SCI). To date, no studies have examined the role of proton extrusion as mechanism of pathological acidosis in SCI.… read more here.
Keywords: acidosis; proton channel; cord; tissue ... See more keywords
Expression and function of voltage gated proton channels (Hv1) in MDA-MB-231 cells
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0227522
Abstract: Expression of the voltage gated proton channel (Hv1) as identified by immunocytochemistry has been reported previously in breast cancer tissue. Increased expression of HV1 was correlated with poor prognosis and decreased overall and disease-free survival… read more here.
Keywords: 231 cells; mda 231; breast cancer; expression ... See more keywords
Role of voltage-gated proton channel (Hv1) in cancer biology
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1175702
Abstract: The acid-base characteristics of tumor cells and the other elements that compose the tumor microenvironment have been topics of scientific interest in oncological research. There is much evidence confirming that pH conditions are maintained by… read more here.
Keywords: voltage gated; proton channel; biology; gated proton ... See more keywords
Voltage-Gated Proton Channel Hv1 Regulates Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson’s Disease Models
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DOI: 10.3390/antiox12030582
Abstract: Although the precise mechanisms for neurodegeneration in Parkinson’s disease (PD) are unknown, evidence suggests that neuroinflammation is a critical factor in the pathogenic process. Here, we sought to determine whether the voltage-gated proton channel, Hv1… read more here.
Keywords: neurodegeneration parkinson; voltage gated; parkinson disease; neurodegeneration ... See more keywords
Gating Mechanism of the Voltage-Gated Proton Channel Studied by Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27072277
Abstract: The voltage-gated proton channel Hv1 has important roles in proton extrusion, pH homeostasis, sperm motility, and cancer progression. The Hv1 channel has also been found to be highly expressed in cell lines and tissue samples… read more here.
Keywords: proton channel; gating mechanism; voltage gated; hv1 ... See more keywords