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   Articles with "hvem" as a keyword



HVEM network signaling in cancer.

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recommendations! Published in 2019 at "Advances in cancer research"

DOI: 10.1016/bs.acr.2019.01.004

Abstract: Somatic mutations in cancer cells may influence tumor growth, survival, or immune interactions in their microenvironment. The tumor necrosis factor receptor family member HVEM (TNFRSF14) is frequently mutated in cancers and has been attributed a… read more here.

Keywords: hvem network; role; hvem; cancer ... See more keywords

The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis

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recommendations! Published in 2019 at "Immunity"

DOI: 10.1016/j.immuni.2019.05.022

Abstract: Summary The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell lymphomas. We found that HVEM deficiency increased B cell competitiveness during… read more here.

Keywords: germinal center; hvem btla; hvem; functions cell ... See more keywords

HVEM has a broader expression than PD-L1 and constitutes a negative prognostic marker and potential treatment target for melanoma

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recommendations! Published in 2019 at "Oncoimmunology"

DOI: 10.1080/2162402x.2019.1665976

Abstract: ABSTRACT HVEM (Herpes Virus Entry Mediator) engagement of BTLA (B and T Lymphocyte Attenuator) triggers inhibitory signals in T cells and could play a role in evading antitumor immunity. Here, HVEM expression levels in melanoma… read more here.

Keywords: expression; hvem; marker; hvem expression ... See more keywords

Anti-HVEM mAb therapy improves antitumoral immunity both in vitro and in vivo, in a novel transgenic mouse model expressing human HVEM and BTLA molecules challenged with HVEM expressing tumors

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recommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"

DOI: 10.1136/jitc-2022-006348

Abstract: Background Tumor necrosis factor superfamily member 14 (TNFRSF14)/herpes virus entry mediator (HVEM) is the ligand for B and T lymphocyte attenuator (BTLA) and CD160-negative immune co-signaling molecules as well as viral proteins. Its expression is… read more here.

Keywords: mouse; btla; expressing human; hvem ... See more keywords

BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.956694

Abstract: The engagement of the herpesvirus entry mediator (HVEM, TNFRSF14) by the B and T lymphocyte attenuator (BTLA) represents a unique interaction between an activating receptor of the TNFR-superfamily and an inhibitory receptor of the Ig-superfamily.… read more here.

Keywords: inhibition; dominant role; btla; btla hvem ... See more keywords

Herpes virus entry mediator signaling blockade produces mortality in neonatal sepsis through induced cardiac dysfunction

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recommendations! Published in 2024 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2024.1365174

Abstract: Introduction Sepsis remains a major source of morbidity and mortality in neonates, and characterization of immune regulation in the neonatal septic response remains limited. HVEM is a checkpoint regulator which can both stimulate or inhibit… read more here.

Keywords: cardiac dysfunction; blockade; mortality; hvem ... See more keywords

Effect of HVEM/CD160 Variations on the Clear Cell Renal Carcinoma Risk and Overall Survival

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recommendations! Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms25136860

Abstract: Renal cell carcinoma (RCC) accounts for approximately 90–95% of all kidney cancers in adults, with clear cell RCC (ccRCC) being the most frequently identified subtype. RCC is known for its responsiveness to immunotherapy, making it… read more here.

Keywords: hvem cd160; risk; hvem; overall survival ... See more keywords

Analysis of Immune Checkpoints on Peripheral Blood Mononuclear Cells Can Predict Clinical Outcome and Reveal Potential of HVEM-BTLA Axis in Epithelial Ovarian Cancers

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recommendations! Published in 2025 at "Pharmaceuticals"

DOI: 10.3390/ph18091295

Abstract: Background/Objectives: Immune checkpoint inhibitors (ICIs) do not provide promising benefits to patients with advanced epithelial ovarian cancer (EOC). This study analyzed preoperative peripheral blood mononuclear cells (PBMCs) from these patients to evaluate the prognostic and… read more here.

Keywords: peripheral blood; epithelial ovarian; hvem; btla ... See more keywords