HVEM network signaling in cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in cancer research"
DOI: 10.1016/bs.acr.2019.01.004
Abstract: Somatic mutations in cancer cells may influence tumor growth, survival, or immune interactions in their microenvironment. The tumor necrosis factor receptor family member HVEM (TNFRSF14) is frequently mutated in cancers and has been attributed a… read more here.
Keywords: hvem network; role; hvem; cancer ... See more keywords
The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis
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DOI: 10.1016/j.immuni.2019.05.022
Abstract: Summary The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell lymphomas. We found that HVEM deficiency increased B cell competitiveness during… read more here.
Keywords: germinal center; hvem btla; hvem; functions cell ... See more keywords
HVEM has a broader expression than PD-L1 and constitutes a negative prognostic marker and potential treatment target for melanoma
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DOI: 10.1080/2162402x.2019.1665976
Abstract: ABSTRACT HVEM (Herpes Virus Entry Mediator) engagement of BTLA (B and T Lymphocyte Attenuator) triggers inhibitory signals in T cells and could play a role in evading antitumor immunity. Here, HVEM expression levels in melanoma… read more here.
Keywords: expression; hvem; marker; hvem expression ... See more keywords
Anti-HVEM mAb therapy improves antitumoral immunity both in vitro and in vivo, in a novel transgenic mouse model expressing human HVEM and BTLA molecules challenged with HVEM expressing tumors
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006348
Abstract: Background Tumor necrosis factor superfamily member 14 (TNFRSF14)/herpes virus entry mediator (HVEM) is the ligand for B and T lymphocyte attenuator (BTLA) and CD160-negative immune co-signaling molecules as well as viral proteins. Its expression is… read more here.
Keywords: mouse; btla; expressing human; hvem ... See more keywords
BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM
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DOI: 10.3389/fimmu.2022.956694
Abstract: The engagement of the herpesvirus entry mediator (HVEM, TNFRSF14) by the B and T lymphocyte attenuator (BTLA) represents a unique interaction between an activating receptor of the TNFR-superfamily and an inhibitory receptor of the Ig-superfamily.… read more here.
Keywords: inhibition; dominant role; btla; btla hvem ... See more keywords