Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes
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DOI: 10.1371/journal.pone.0267921
Abstract: Synovial fluid is composed of hyaluronan and proteoglycan-4 (PRG4 or lubricin), which work synergistically to maintain joint lubrication. In diseases like osteoarthritis, hyaluronan and PRG4 concentrations can be altered, resulting in lowered synovial fluid viscosity,… read more here.
Keywords: endogenous production; hyaluronan prg4; cyclic loading; concentration ... See more keywords