Molecular Insights into Therapeutic Potentials of Hybrid Compounds Targeting Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02779-6
Abstract: Alzheimer's disease (AD) is one of the most complex progressive neurological disorders involving degeneration of neuronal connections in brain cells leading to cell death. AD is predominantly detected among elder people (> 65 years), mostly diagnosed with… read more here.
Keywords: therapeutic compounds; hybrid compounds; hybrid molecules; molecular insights ... See more keywords
1,3,4-Thiadiazoline−coumarin hybrid compounds containing D-glucose/D-galactose moieties: Synthesis and evaluation of their antiproliferative activity
Sign Up to like & getrecommendations! Published in 2021 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2021.103053
Abstract: Abstract We synthesized a new series of 1,3,4-thiadiazoline−coumarin hybrid compounds that contain d -glucose and d -galactose moieties (9a-g) and evaluated their cytotoxic activity against breast adenocarcinoma (MCF-7), human liver cancer (HepG2), human cervical cancer… read more here.
Keywords: glucose galactose; coumarin hybrid; cancer; thiadiazoline coumarin ... See more keywords
A facile approach to hybrid compounds containing a tricyclic diterpenoid and fluorine-substituted heterocycles
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2020.109554
Abstract: Abstract 2,3-Butadienes have become valuable building blocks in the synthesis of various heterocyclic compounds. The Pd-catalyzed cross-coupling and cyclization reaction of N-(2,3-butadienyl)carboxamide of isopimaric acid with fluorine-substituted 2-iodophenols proceeds with the formation of optically active… read more here.
Keywords: fluorine substituted; containing tricyclic; tricyclic diterpenoid; hybrid compounds ... See more keywords
Hybrid compounds for improving drugs solubility: Synthesis, physico-chemical and pharmaceutical characterization of Nimesulide-LDH
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Solid State Chemistry"
DOI: 10.1016/j.jssc.2019.02.001
Abstract: Abstract Layered double hydroxides (LDHs) with their sheets structure are undoubtedly interesting inorganic hosts for different applications, in particular for drug delivery. Nimesulide, a poorly soluble anti-inflammatory drug, could benefit of the association with LDH… read more here.
Keywords: improving drugs; drugs solubility; drug; solubility synthesis ... See more keywords
Two Keggin polyoxometalate-based hybrid compounds with different helix: Syntheses, structure and catalytic activities
Sign Up to like & getrecommendations! Published in 2017 at "Polyhedron"
DOI: 10.1016/j.poly.2017.04.017
Abstract: Abstract By adjusting pH value, two new Keggin polyoxometalate-based hybrid compounds with different helical structure, [Ag6(btp)(pyttz)6·(HSiMo12O40)2]·4H2O (1) and [Ag2(pyttz)4·(H2SiMo12O40)2]·(TMA)2·4H2O (2), (pyttz = 3-(pyrid-4-yl)-5-(1 H-1,2,4–3-yl)-1,2,4-triazolyl, btp = 5,5′-di(pyridin-4-yl)-1 H,1′H-3,3′-bi(1,2,4-triazole), TMA = tetramethylammonium), were successfully isolated by hydrothermal reaction and structurally characterized. Structural analysis shows… read more here.
Keywords: polyoxometalate based; compounds different; catalytic activities; hybrid compounds ... See more keywords
Synthesis and characterization of new organic–inorganic hybrid compounds based on Sb, with a perovskite like structure
Sign Up to like & getrecommendations! Published in 2018 at "Polyhedron"
DOI: 10.1016/j.poly.2018.05.024
Abstract: Abstract Two new perovskite-related organic–inorganic hybrid compounds, based on Sb were synthesized and characterized. Their structure, optical and vibronic properties were studied. The benzylamine antimonium iodide (C6H5CH2NH3)3Sb2I9 has a 0 dimensional structure consisting of two… read more here.
Keywords: organic inorganic; compounds based; inorganic hybrid; hybrid compounds ... See more keywords
Design and semisynthesis of new herbicide as 1,2,3-triazole derivatives of the natural maslinic acid
Sign Up to like & getrecommendations! Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2018.07.004
Abstract: Graphical abstract Figure. No Caption available. HighlightsNew hybrid compounds based on maslinic acid (MA) from Olea europaea were synthesized.The semisynthesis was achieved through CuAAC under microwave conditions.Development of new inhibitors (up to 100%) of Lactuca… read more here.
Keywords: maslinic acid; new herbicide; semisynthesis new; hybrid compounds ... See more keywords
Visible-Light-Driven Oxidation of Amines to Imines in Air Catalyzed by Polyoxometalate-Tris(bipyridine)ruthenium Hybrid Compounds.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c01243
Abstract: The development of visible-light photocatalysts for the selective oxidative coupling of amines to imines is an area of great interest. Herein, four hybrid compounds based on polyoxometalate anions and tris(bipyridine)ruthenium cations, Ru(bpy)3[M6O19] (M = Mo,… read more here.
Keywords: bipyridine ruthenium; amines imines; spectroscopy; hybrid compounds ... See more keywords
Multifunctional Hybrid Compounds Derived from 2-(2,5-Dioxopyrrolidin-1-yl)-3-methoxypropanamides with Anticonvulsant and Antinociceptive Properties.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01114
Abstract: The focused set of new pyrrolidine-2,5-diones as potential broad-spectrum hybrid anticonvulsants was described. These derivatives integrate on the common structural scaffold the chemical fragments of well-known antiepileptic drugs such as ethosuximide, levetiracetam, and lacosamide. Such… read more here.
Keywords: derived dioxopyrrolidin; hybrid compounds; seizure models; compounds derived ... See more keywords
Synthesis and inhibitory activity against MurA and MurZ enzymes of 4H-pyrano[2,3-d]pyrimidine−1H-1,2,3-triazole hybrid compounds having piperidine and morpholine rings
Sign Up to like & getrecommendations! Published in 2023 at "New Journal of Chemistry"
DOI: 10.1039/d3nj01718d
Abstract: A series of D-glucose-conjugated 4H-pyrano[2,3-d]pyrimidine−1H-1,2,3-triazole hybrid compounds 12a-g & 13a-g having piperidine and morpholine rings were synthesized by click chemistry between corresponding propargyl derivatives and azide of D-glucose using CuI@Montmorillonite... read more here.
Keywords: piperidine morpholine; chemistry; pyrimidine triazole; hybrid compounds ... See more keywords
Two organic–inorganic hybrid compounds constructed from [PMoV1MoVI7VIV2VV4O42]4− and different transition metal fragments
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Coordination Chemistry"
DOI: 10.1080/00958972.2017.1278755
Abstract: Abstract Two new organic–inorganic hybrid compounds, [Cu(phen)(prz)]2[PMoV1MoVI7VIV2VV4O42]·4H2O (1) and [Ag2(phen)4]2[PMoV1MoVI7VIV2VV4O42] (2) (phen = 1,10-phenanthroline, prz = pyrazine), have been synthesized and characterized by IR, XPS, XRD, UV–vis, fluorescent spectra analyses, elemental analyses, X-ray diffraction analyses,… read more here.
Keywords: metal fragments; transition metal; organic inorganic; constructed pmov1movi7viv2vv4o42 ... See more keywords