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Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02779-6
Abstract: Alzheimer's disease (AD) is one of the most complex progressive neurological disorders involving degeneration of neuronal connections in brain cells leading to cell death. AD is predominantly detected among elder people (> 65 years), mostly diagnosed with…
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Keywords:
therapeutic compounds;
hybrid compounds;
hybrid molecules;
molecular insights ... See more keywords
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Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.05.014
Abstract: Designing of hybrid drugs with specific multitarget profile is a promising line of attack against inflammation. In light of this, a series of benzimidazole scaffold based hybrid molecules were designed by integrating benzimidazoles (containing pharmacophoric…
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Keywords:
hybrid molecules;
scaffold based;
benzimidazole scaffold;
lox ... See more keywords
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Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.102997
Abstract: One of the helpful ways to improve the effectiveness of anticancer agents and weaken drug resistance is to use hybrid molecules. therefore, the current study intended to introduce 20 novel xanthine/chalcone hybrids 9-28 of promising…
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Keywords:
hybrid molecules;
novel xanthine;
anticancer activity;
effect ... See more keywords
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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.04.028
Abstract: Hybrid molecules are used as anticancer agents to improve effectiveness and diminish drug resistance. So, the current study aimed to introduce twenty novel phenothiazine sulfonamide hybrids 5-22, 24 and 25 of promising anticancer activity. Compounds…
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Keywords:
hybrid molecules;
anticancer activity;
effect;
novel phenothiazine ... See more keywords
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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.09.069
Abstract: Heterocyclic compounds are the interesting core structures for the development of new bioactive compounds. Fatty acids are derived from renewable raw materials and exhibit various biological activities. Several researchers are amalgamating these two bioactive components…
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Keywords:
hybrid molecules;
biological activities;
fatty acid;
chemistry ... See more keywords
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Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2018.06.004
Abstract: Graphical abstract Figure. No Caption available. HighlightsSynthesis of steroid containing 5Z,9Z‐dienoic acids have been developed.New molecules are efficient apoptosis inducers in cancer cells.The structures of all novel compounds were confirmed by NMR measurements. ABSTRACT Hybrid…
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Keywords:
hybrid molecules;
molecules based;
chemistry;
antitumor activity ... See more keywords
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Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00259
Abstract: Peptides and oligonucleotides are two of the most interesting molecular platforms for making bioactive materials. Peptides provide bioactivity that can mimic that of proteins, whereas oligonucleotides like DNA can be used as scaffolds to immobilize…
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Keywords:
hybrid molecules;
dna;
peptide oligonucleotide;
molecules bioactive ... See more keywords
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Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00123
Abstract: Protein misfolding and amyloid formation are associated with various human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and Type-2 Diabetes mellitus (T2DM). No disease-modifying therapeutics are available for them. Despite the lack of sequence…
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Keywords:
hybrid molecules;
alzheimer disease;
disease;
formation ... See more keywords
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Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03428
Abstract: We managed to obtain three different series of 2,3-dimethyl-1,4-benzoquinones, named nonhalogenated and halogenated (brominated and chlorinated) PQ analogues, via the molecular hybridization strategy. Sixteen of eighteen hybrid molecules were selected by the National Cancer Institute…
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Keywords:
hybrid molecules;
cell;
cipq1;
t47d ... See more keywords
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Published in 2019 at "New Journal of Chemistry"
DOI: 10.1039/c9nj00473d
Abstract: Biologically active semicarbazone-triazole hybrid molecules designed and synthesized from semicarbazone linked with a terminal alkyne and aromatic azidesviaCu(i)-catalyzed cycloaddition reaction. The synthesized compounds exhibited potent antibacterial activities against the tested bacterial strains. Computational results are…
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Keywords:
hybrid molecules;
semicarbazone;
molecular docking;
biologically active ... See more keywords
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Published in 2021 at "Photochemistry and photobiology"
DOI: 10.1111/php.13539
Abstract: Hybrid molecules based on fullerene C60 and dithienylethene and its perfluorinated analogue not inferior in the efficiency of phototransformations to the initial photochromic compounds were synthesized for the first time. The resulting pyrrolidinofullerenes containing photochromic…
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Keywords:
hybrid molecules;
based fullerene;
molecules based;
fullerene c60 ... See more keywords