Antimicrobial Peptides with Rigid Linkers against Gram-Negative Bacteria by Targeting Lipopolysaccharide.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c05921
Abstract: A series of hybrid peptides were designed by connecting an antimicrobial peptide Ce(1-8) with a lipopolysaccharide (LPS)-targeting peptide Lf(28-34) via different linkers. Antimicrobial experimental results indicated that linkers play an essential role in the anti-Gram-negative… read more here.
Keywords: peptides rigid; hybrid peptides; antimicrobial peptides; rigid linkers ... See more keywords
Overall Shape Constraint of Alternating α/β-Hybrid Peptides Containing Bicyclic β-Proline.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02799
Abstract: Our NMR, IR/Raman, CD spectroscopic, and X-ray crystallographic studies, as well as accelerated molecular dynamics simulations, showed that alternating hybrid α/β-peptides containing a bicyclic β-proline surrogate form unique extended curved folds, regardless of the peptide… read more here.
Keywords: alternating hybrid; bicyclic proline; containing bicyclic; peptides containing ... See more keywords
Dimeric lipo-α/sulfono-γ-AA hybrid peptides as broad-spectrum antibiotic agents.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials science"
DOI: 10.1039/d0bm01955k
Abstract: There is an urgent need to develop novel antibiotic agents that can combat emerging drug resistance. Herein, we report the design and investigation of a class of short dimeric antimicrobial lipo-α/sulfono-γ-AA hybrid peptides. Some of… read more here.
Keywords: hybrid peptides; lipo sulfono; sulfono hybrid; dimeric lipo ... See more keywords
P53-derived hybrid peptides induce apoptosis of synovial fibroblasts in the rheumatoid joint
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.23268
Abstract: Loss of p53-mediated suppression by its dominant-negative counterpart is commonly observed in human cancers, and activating p73 is a therapeutic strategy in p53-mutated oncological patients. In synovial fibroblasts (SFs) from rheumatoid arthritis (RA), mutant p53… read more here.
Keywords: derived hybrid; p53 derived; hybrid peptides; induce apoptosis ... See more keywords
Multiple Antimicrobial Effects of Hybrid Peptides Synthesized Based on the Sequence of Ribosomal S1 Protein from Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23010524
Abstract: The need to develop new antimicrobial peptides is due to the high resistance of pathogenic bacteria to traditional antibiotics now and in the future. The creation of synthetic peptide constructs is a common and successful… read more here.
Keywords: ribosomal protein; protein staphylococcus; hybrid peptides; antimicrobial peptides ... See more keywords