Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter
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DOI: 10.1093/nar/gky1179
Abstract: Abstract Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as an attractive target for cancer therapy due to its key role in DNA repair processes. Inhibition of PARP1 in BRCA-mutated cancers has been observed to be… read more here.
Keywords: parp1 promoter; structure; hybrid quadruplex; parp1 ... See more keywords