Hybrid thermophilic/mesophilic enzymes reveal a role for conformational disorder in regulation of bacterial Enzyme I.
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DOI: 10.1016/j.jmb.2020.05.024
Abstract: Conformational disorder is emerging as an important feature of biopolymers, regulating a vast array of cellular functions, including signaling, phase separation, and enzyme catalysis. Here we combine NMR, crystallography, computer simulations, protein engineering, and functional… read more here.
Keywords: hybrid thermophilic; bacterial enzyme; enzyme; conformational disorder ... See more keywords