Framework Nucleic Acids Combined with 3D Hybridization Chain Reaction Amplifiers for Monitoring Multiple Human Tear Cytokines
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202400622
Abstract: Existing tear sensors are difficult to perform multiplexed assays due to the minute amounts of biomolecules in tears and the tiny volume of tears. Herein, the authors leverage DNA tetrahedral frameworks (DTFs) modified on the… read more here.
Keywords: monitoring multiple; chain reaction; hybridization chain;
Hybridization Chain Reaction Design and Biosensor Implementation.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8582-1_8
Abstract: DNA biosensors could overcome some of the common drawbacks of lab-based techniques for nucleic acids detection for diagnostics purposes. One of the main impediments for such applications of DNA biosensors is their lack of sensitivity:… read more here.
Keywords: hybridization chain; chain reaction; dna biosensors;
Magnetic beads-based DNA hybridization chain reaction amplification and DNAzyme recognition for colorimetric detection of uranyl ion in seafood.
Sign Up to like & getrecommendations! Published in 2017 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2016.12.021
Abstract: A novel colorimetric biosensor, which employs DNAzyme-functionalized magnetic beads (MBs) as recognition probe, enzyme-assisted catalytic oxidation of TMB (3,3',5,5'-tetramethylbenzidine sulfate) as signal and DNA hybridization chain reaction as amplification strategy, has been developed for detecting… read more here.
Keywords: dna hybridization; hybridization chain; chain reaction;
A signal-flexible gene diagnostic strategy coupling loop-mediated isothermal amplification with hybridization chain reaction
Sign Up to like & getrecommendations! Published in 2019 at "Analytica Chimica Acta"
DOI: 10.1016/j.aca.2019.06.048
Abstract: Abstract Recent study proves that the combination of loop mediated isothermal nucleic acid amplification (LAMP) with one-step strand displacement (OSD) is of great help to improve the sequence specificity during genetic detection. However, because OSD… read more here.
Keywords: loop mediated; mediated isothermal; hybridization chain; chain reaction ... See more keywords
A ratiometric electrochemical assay for human 8-oxoguanine DNA glycosylase amplified by hybridization chain reaction
Sign Up to like & getrecommendations! Published in 2019 at "Electrochemistry Communications"
DOI: 10.1016/j.elecom.2019.05.006
Abstract: Abstract Human 8-oxoguanine DNA glycosylase 1 (hOGG1) is an important DNA repair enzyme, which is closely related to the occurrence and development of certain diseases. Ultrasensitive and accurate detection of hOGG1 is significant for fundamental… read more here.
Keywords: oxoguanine dna; dna; dna glycosylase; ratiometric electrochemical ... See more keywords
Highly sensitive antibody-aptamer sensor for vascular endothelial growth factor based on hybridization chain reaction and pH meter/indicator.
Sign Up to like & getrecommendations! Published in 2017 at "Talanta"
DOI: 10.1016/j.talanta.2017.04.073
Abstract: Vascular endothelial growth factor (VEGF) is a crucial signaling protein for the tumor growth and metastasis, which is also acted as the biomarkers for various diseases. In this research, we fabricate an aptamer-antibody sensor for… read more here.
Keywords: hybridization chain; vascular endothelial; endothelial growth; antibody ... See more keywords
Proximity hybridization triggered hybridization chain reaction for label-free electrochemical homogeneous aptasensors.
Sign Up to like & getrecommendations! Published in 2021 at "Talanta"
DOI: 10.1016/j.talanta.2020.122058
Abstract: A label-free homogeneous electrochemical aptasensor was developed for detection of thrombin based on proximity hybridization triggered hybridization chain reaction induced G-quadruplex formation. Thrombin promoted the formation of a complex via the proximity hybridization of the… read more here.
Keywords: hybridization chain; proximity hybridization; hybridization; chain reaction ... See more keywords
Hybridization chain reaction and its applications in biosensing.
Sign Up to like & getrecommendations! Published in 2021 at "Talanta"
DOI: 10.1016/j.talanta.2021.122637
Abstract: To pursue the sensitive and efficient detection of informative biomolecules for bioanalysis and disease diagnosis, a series of signal amplification techniques have been put forward. Among them, hybridization chain reaction (HCR) is an isothermal and… read more here.
Keywords: chain reaction; hybridization chain; reaction; hcr ... See more keywords
Light-Controlled Recruitable Hybridization Chain Reaction on Exosome Vehicles for Highly Sensitive MicroRNA Imaging in Living Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00974
Abstract: Sensitive imaging of intracellular microRNA (miRNA) in living cells is of great significance. Isothermal hybridization chain reaction (HCR)-based methods, although have been widely used to monitor intracellular low-abundance miRNA, are still subjected to the challenges… read more here.
Keywords: hybridization chain; light controlled; chain reaction; controlled recruitable ... See more keywords
A Reciprocal-Amplifiable Fluorescence Sensing Platform via Replicated Hybridization Chain Reaction for Hosting Concatenated Multi-Ag Nanoclusters as Signal Reporter.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03782
Abstract: Exploring the replication of hybridization chain reaction HCR (rHCR) for reciprocal amplification is intriguing in biosensing and bioanalysis. Herein, we develop a rHCR-based fluorescence platform that is manipulated by the combination of a specific DNA… read more here.
Keywords: hybridization chain; chain reaction; rhcr; hybridization ... See more keywords
Ultrasensitive Hybridization Chain Reaction-Assisted Multisite Exonuclease III Amplification Strategy Combined with a Direct Quantitative Fluorescence Lateral Flow Technique for Multiple Bacterial 16S rRNA Detection.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.3c00270
Abstract: Accurate and in-time detection of bacteria conduces to preventing their rapid spread around the environment, while a nucleic acid test (NAT) is a powerful tool for early diagnosis of pathogens. Herein, we propose a hybridization… read more here.
Keywords: hybridization chain; 16s rrna; amplification; iii ... See more keywords